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QuickView for Tiaprofenic acid (compound)

Name: tiaprofenic acid
PubChem Compound ID: 10355289
Molecular formula: C14H12O3S
Molecular weight: 261.315 g/mol
Name: tiaprofenic acid
Name (isomeric): DB01600
Drug Type: small molecule
Acidum tiaprofenicum [inn-latin]; 2-(5-Benzyl-2-thienyl)propionsaeure; Acido tiaprofenico [inn-spanish]; Acide tiaprofenique [inn-french]; 5-Benzoyl-alpha-methyl-2-thiopheneacetic acid; Tiaprofensaeure
Brand: Novo-Tiaprofenic, Tiaprofenic-200 - Tab, Tiaprofenic-300 - Tab, Nu-Tiaprofenic, Apo-Tiaprofenic Tablets, PMS-tiaprofenic, Surgam, Dom-tiaprofenic, Surgam SR
CAS number: 33005-95-7
Indication: Tiaprofenic acid is used to treat pain, especially arthritic pain.
Pharmacology: Tiaprofenic acid is a non-steroidal anti-inflammatory drug of the arylpropionic acid (profen) class, used to treat pain, especially arthritic pain. The typical adult dose is 300mg twice daily. It is not recommended in children.
Mechanism of Action: Tiaprofenic acid belongs to a group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). It works by blocking the production of a chemical (prostaglandin) which the body produces in response to injury or certain diseases. This prostaglandin would otherwise go on to cause swelling, pain and inflammation.
Absorption: Bioavailability is 90% following oral administration.
Biotransformation: Hepatic (10%). Sparingly metabolised in the liver to two inactive metabolites.
Half Life: 1.5-2.5 hours
Affected organisms: Humans and other mammals
Food interaction:
Avoid alcohol.
Take with food.
Drug interaction:
MethotrexateTiaprofenic acid may decrease renal excretion of methotrexate. Consider alternate therapy or monitor for methotrexate toxicity.
EscitalopramAdditive antiplatelet effects increase the risk of bleeding. Consider alternate therapy or monitor for increased bleeding.
Aminosalicylic AcidIncreased risk of gastrointestinal bleeding.
CholestyramineThe bile acid sequestrant, Cholestyramine resin, may reduce Tiaprofenic acid absorption and therapeutic effect.
PemetrexedTiaprofenic acid may decrease Pemetrexed excretion. Tiaprofenic acid should not be used around the time when Pemetrexed is administered.
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