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QuickView for Ticam1 (gene)


Gene Symbol:
TICAM1 Homo sapiens Homo sapiens
Full name:
toll like receptor adaptor molecule 1
Synonyms:
IIAE6, MyD88-3, PRVTIRB, TICAM-1, TRIF, TIR domain-containing adapter molecule 1, TIR domain containing adaptor inducing interferon-beta, TIR domain-containing adapter protein inducing IFN-beta, proline-rich, vinculin and TIR domain-containing protein B, putative NF-kappa-B-activating protein 502H, toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta
Genomic Location:
Chr 19: 4766992-4769451
Description:
This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically ...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Danio rerio Pan troglodytes Bos taurus Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 19
19p13.3


Transcripts Names
NM_182919
NM_014261
Protein Names
B3Y691
Q8IUC6
Q86XP8
O75532
Q96GA0



GO Molecular Function

kinase binding | protein kinase binding | enzyme binding | protein binding

GO Biological Process

positive regulation of immune response | positive regulation of macromolecule biosynthetic process | response to virus | negative regulation of immune system process | regulation of B cell activation | immune response-regulating signaling pathway | response to lipopolysaccharide | intracellular signal transduction | negative regulation of MyD88-independent toll-like receptor signaling pathway | positive regulation of DNA-binding transcription factor activity | defense response to other organism | necroptotic process | regulation of autophagy | regulation of immune system process | regulation of nitric oxide biosynthetic process | negative regulation of cellular process | positive regulation of lymphocyte activation | regulation of interferon-beta biosynthetic process | defense response | innate immune response-activating signal transduction | positive regulation of cellular biosynthetic process | cellular process | toll-like receptor signaling pathway | response to exogenous dsRNA | regulation of cytokine biosynthetic process | negative regulation of signaling | positive regulation of reactive oxygen species metabolic process | programmed necrotic cell death | regulation of MyD88-independent toll-like receptor signaling pathway | positive regulation of nitrogen compound metabolic process | regulation of binding | cellular response to oxidised low-density lipoprotein particle stimulus | regulation of interferon-beta production | regulation of immune response | regulation of cellular process | leukocyte activation | cellular response to lipid | regulation of metabolic process | cellular response to molecule of bacterial origin | positive regulation of cellular protein metabolic process | regulation of natural killer cell activation | negative regulation of toll-like receptor signaling pathway | positive regulation of protein binding | positive regulation of tumor necrosis factor production | regulation of type I interferon production | response to stimulus | positive regulation of innate immune response | positive regulation of nitric oxide metabolic process | positive regulation of immune system process | positive regulation of protein metabolic process | response to stress | positive regulation of chemokine biosynthetic process | leukocyte activation involved in immune response | positive regulation of lymphocyte proliferation | regulation of cell proliferation | regulation of protein ubiquitination | positive regulation of B cell proliferation | regulation of protein homodimerization activity | programmed cell death | positive regulation of cytokine biosynthetic process | positive regulation of cell activation | activation of innate immune response | positive regulation of natural killer cell activation | response to molecule of bacterial origin | immune response-activating signal transduction | regulation of nucleic acid-templated transcription | regulation of neurotransmitter levels | response to nitrogen compound | apoptotic process | positive regulation of reactive oxygen species biosynthetic process | positive regulation of mononuclear cell proliferation | response to external biotic stimulus | regulation of signal transduction | pattern recognition receptor signaling pathway | regulation of toll-like receptor signaling pathway | positive regulation of inflammatory response | response to dsRNA | regulation of gene expression | response to lipid | positive regulation of cellular metabolic process | defense response to virus | regulation of lymphocyte activation | regulation of nitrogen compound metabolic process | positive regulation of intracellular signal transduction | positive regulation of cytokine production involved in inflammatory response | macrophage activation involved in immune response | regulation of cytokine production involved in inflammatory response | regulation of cellular protein metabolic process | TRIF-dependent toll-like receptor signaling pathway | positive regulation of chemokine production | regulation of tumor necrosis factor production | response to bacterium | cell communication | regulation of cellular metabolic process | positive regulation of interferon-beta biosynthetic process | inflammatory response | cell activation involved in immune response | myeloid cell activation involved in immune response | regulation of protein metabolic process | positive regulation of signal transduction | positive regulation of cell proliferation | regulation of RNA metabolic process | lipopolysaccharide-mediated signaling pathway | positive regulation of B cell activation | apoptotic signaling pathway | cellular response to lipoprotein particle stimulus | positive regulation of molecular function | activation of immune response | positive regulation of protein modification process | response to organic substance | regulation of innate immune response | MyD88-independent toll-like receptor signaling pathway | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | cell surface receptor signaling pathway | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | positive regulation of interleukin-6 production | macrophage activation | immune response | cell death | regulation of cell activation | positive regulation of NF-kappaB transcription factor activity | positive regulation of binding | positive regulation of autophagy | positive regulation of cytokine production | cell activation | toll-like receptor 3 signaling pathway | regulation of reactive oxygen species biosynthetic process | regulation of cell communication | negative regulation of signal transduction | signaling | positive regulation of I-kappaB kinase/NF-kappaB signaling | regulation of transcription, DNA-templated | regulation of protein binding | response to organic cyclic compound | I-kappaB kinase/NF-kappaB signaling | regulation of cytokine production | response to biotic stimulus | regulation of chemokine production | regulation of reactive oxygen species metabolic process | necrotic cell death | regulation of B cell proliferation | innate immune response | response to organonitrogen compound | positive regulation of nitric oxide biosynthetic process | positive regulation of metabolic process | immune system process | cellular response to organic substance | positive regulation of type I interferon production | regulation of interleukin-6 production | regulation of inflammatory response | positive regulation of protein ubiquitination | regulation of I-kappaB kinase/NF-kappaB signaling | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | cellular response to lipopolysaccharide | positive regulation of interferon-beta production

GO Cellular Component

ripoptosome | intracellular membrane-bounded organelle | catalytic complex | organelle membrane | cytoplasmic vesicle | cell | cytoplasm | intracellular organelle | endosome membrane | protein-containing complex | endomembrane system | vacuole | vesicle | endosome | membrane-bounded organelle | organelle | cytosol | intracellular vesicle | intracellular | autophagosome | membrane