QuickView for Ticam2 (gene)
- Gene Symbol:
- TICAM2
Homo sapiens - Full name:
- toll like receptor adaptor molecule 2
- Synonyms:
- MyD88-4, TICAM-2, TIRAP3, TIRP, TRAM, TIR domain-containing adapter molecule 2, NF-kappa-B-activating protein 502, TRIF-related adaptor molecule, cytoplasmic adaptor, putative NF-kappa-B-activating protein 502, toll-like receptor adaptor protein 3, toll/interleukin-1 receptor (TIR) domain-containing adapter protein
- Genomic Location:
- Chr 5: 114942247-114989610
- Description:
-
TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4; MIM 603030).
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
5q22.3
GO Molecular Function
lipid binding | phospholipid binding | anion binding | ion binding | protein binding
GO Biological Process
positive regulation of immune response | response to virus | negative regulation of immune system process | exocytosis | response to cytokine | immune response-regulating signaling pathway | neutrophil activation | response to lipopolysaccharide | intracellular signal transduction | negative regulation of MyD88-independent toll-like receptor signaling pathway | defense response to other organism | necroptotic process | establishment of localization | regulation of immune system process | negative regulation of cellular process | defense response | intracellular transport | regulation of toll-like receptor 4 signaling pathway | innate immune response-activating signal transduction | cellular process | secretion | toll-like receptor signaling pathway | leukocyte degranulation | localization | protein transport | negative regulation of signaling | TRAM-dependent toll-like receptor 4 signaling pathway | programmed necrotic cell death | regulation of MyD88-independent toll-like receptor signaling pathway | macromolecule localization | regulation of response to cytokine stimulus | endomembrane system organization | establishment of localization in cell | regulation of immune response | regulation of cellular process | leukocyte activation | cellular response to lipid | cellular response to molecule of bacterial origin | positive regulation of interferon-gamma production | cellular component organization | negative regulation of toll-like receptor signaling pathway | positive regulation of chemokine (C-C motif) ligand 5 production | response to stimulus | neutrophil degranulation | positive regulation of innate immune response | positive regulation of immune system process | response to stress | intracellular protein transport | leukocyte activation involved in immune response | programmed cell death | activation of innate immune response | cellular localization | secretion by cell | response to molecule of bacterial origin | immune response-activating signal transduction | positive regulation of toll-like receptor 4 signaling pathway | response to interleukin-12 | positive regulation of response to cytokine stimulus | apoptotic process | response to external biotic stimulus | regulation of signal transduction | pattern recognition receptor signaling pathway | regulation of toll-like receptor signaling pathway | leukocyte mediated immunity | organic substance transport | response to lipid | defense response to virus | peptide transport | positive regulation of intracellular signal transduction | vesicle-mediated transport | TRIF-dependent toll-like receptor signaling pathway | regulated exocytosis | positive regulation of chemokine production | response to bacterium | cell communication | inflammatory response | cell activation involved in immune response | myeloid cell activation involved in immune response | positive regulation of signal transduction | neutrophil activation involved in immune response | regulation of cytokine-mediated signaling pathway | Golgi vesicle transport | apoptotic signaling pathway | positive regulation of interleukin-18-mediated signaling pathway | activation of immune response | response to organic substance | regulation of innate immune response | Golgi organization | MyD88-independent toll-like receptor signaling pathway | regulation of intracellular signal transduction | cellular protein localization | amide transport | toll-like receptor 4 signaling pathway | positive regulation of interleukin-6 production | immune response | cell death | establishment of protein localization | positive regulation of cytokine production | cell activation | positive regulation of cytokine-mediated signaling pathway | regulation of cell communication | ER to Golgi vesicle-mediated transport | negative regulation of signal transduction | signaling | positive regulation of I-kappaB kinase/NF-kappaB signaling | I-kappaB kinase/NF-kappaB signaling | protein localization | regulation of cytokine production | cellular macromolecule localization | response to biotic stimulus | organelle organization | regulation of chemokine production | necrotic cell death | innate immune response | neutrophil mediated immunity | regulation of interferon-gamma production | immune system process | cellular response to organic substance | regulation of interleukin-6 production | regulation of I-kappaB kinase/NF-kappaB signaling | positive regulation of toll-like receptor signaling pathway | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | cellular response to lipopolysaccharide
GO Cellular Component
secretory granule | endoplasmic reticulum-Golgi intermediate compartment | intracellular membrane-bounded organelle | early endosome membrane | late endosome | organelle membrane | cytoplasmic vesicle | cell | late endosome membrane | COPII-coated ER to Golgi transport vesicle | cytoplasm | intracellular organelle | endoplasmic reticulum | secretory granule membrane | endosome membrane | Golgi apparatus | secretory vesicle | endomembrane system | plasma membrane | Golgi-associated vesicle | vesicle | endosome | membrane-bounded organelle | organelle | vesicle membrane | cell periphery | early endosome | intracellular vesicle | intracellular | membrane | cytoplasmic vesicle membrane | coated vesicle
