QuickView for Tieg1 (gene)
- Gene Symbol:
- KLF10
Homo sapiens - Full name:
- Kruppel like factor 10
- Synonyms:
- EGR-alpha, EGRA, TIEG, TIEG1, Krueppel-like factor 10, TGFB-inducible early growth response protein 1, early growth response-alpha, transforming growth factor-beta-inducible early growth response protein 1, zinc finger transcription factor TIEG
- Genomic Location:
- Chr 8: 103730188-103737128
- Description:
-
This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple ...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
8q22.3
GO Molecular Function
sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | core promoter binding | cation binding | proximal promoter sequence-specific DNA binding | nucleic acid binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | ion binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | core promoter sequence-specific DNA binding | metal ion binding | heterocyclic compound binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | response to extracellular stimulus | positive regulation of macromolecule biosynthetic process | response to nutrient levels | somatic stem cell population maintenance | regulation of immune system process | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | positive regulation of developmental process | negative regulation of RNA biosynthetic process | bone mineralization | cellular response to extracellular stimulus | positive regulation of cellular biosynthetic process | cellular process | negative regulation of nucleic acid-templated transcription | stem cell population maintenance | cellular response to starvation | response to growth factor | regulation of myeloid cell differentiation | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | tissue development | regulation of myeloid leukocyte differentiation | regulation of cell differentiation | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | response to transforming growth factor beta | response to stimulus | positive regulation of osteoclast differentiation | positive regulation of immune system process | response to stress | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | response to peptide | circadian rhythm | response to starvation | rhythmic process | cellular nitrogen compound metabolic process | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular biosynthetic process | cell-cell signaling | regulation of nucleic acid-templated transcription | response to nitrogen compound | system development | cellular response to nutrient levels | nitrogen compound metabolic process | multicellular organism development | regulation of gene expression | cellular response to stress | cellular response to peptide | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | regulation of transcription by RNA polymerase II | positive regulation of cell differentiation | positive regulation of myeloid cell differentiation | cell proliferation | biosynthetic process | aromatic compound biosynthetic process | cell communication | regulation of cellular metabolic process | transmembrane receptor protein serine/threonine kinase signaling pathway | regulation of RNA metabolic process | cellular response to transforming growth factor beta stimulus | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | response to organic substance | regulation of hemopoiesis | anatomical structure development | cell surface receptor signaling pathway | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | organic substance metabolic process | maintenance of cell number | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | gene expression | biomineral tissue development | transcription, DNA-templated | transforming growth factor beta receptor signaling pathway | regulation of osteoclast differentiation | signaling | regulation of transcription, DNA-templated | cellular macromolecule biosynthetic process | regulation of circadian rhythm | regulation of developmental process | developmental process | negative regulation of transcription by RNA polymerase II | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | ossification | skeletal system development | positive regulation of myeloid leukocyte differentiation | cellular metabolic process | cellular response to organic substance | signal transduction | positive regulation of gene expression | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | cell | intracellular organelle | membrane-bounded organelle | nucleus | organelle | intracellular
