Correlation Engine 2.0
Clear Search sequence regions
Bookmark Forward Export SNPs

QuickView for Timp1 (gene)


Gene Symbol:
TIMP1 Homo sapiens Homo sapiens
Full name:
TIMP metallopeptidase inhibitor 1
Synonyms:
CLGI, EPA, EPO, HCI, TIMP, TIMP-1, metalloproteinase inhibitor 1, collagenase inhibitor, erythroid potentiating activity, fibroblast collagenase inhibitor, tissue inhibitor of metalloproteinases 1
Genomic Location:
Chr X: 47326634-47331134
Description:
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr X
Xp11.3


Transcripts Names
NM_003254
XM_017029766
Protein Names
P01033
Q6FGX5
Q9UCU1
Q14252
B4DJK3



GO Molecular Function

endopeptidase inhibitor activity | cation binding | enzyme binding | enzyme inhibitor activity | signaling receptor binding | molecular function regulator | ion binding | protein binding | zinc ion binding | receptor regulator activity | growth factor activity | receptor ligand activity | cytokine activity | transition metal ion binding | metalloendopeptidase inhibitor activity | peptidase inhibitor activity | enzyme regulator activity | protease binding | metal ion binding

GO Biological Process

negative regulation of membrane protein ectodomain proteolysis | endopeptidase inhibitor activity | exocytosis | extracellular structure organization | response to cytokine | regulation of localization | regulation of programmed cell death | establishment of localization | response to hormone | platelet degranulation | negative regulation of cellular process | defense response | negative regulation of proteolysis | cellular process | secretion | regulation of trophoblast cell migration | regulation of cell motility | localization | regulation of integrin-mediated signaling pathway | tissue remodeling | negative regulation of apoptotic process | regulation of proteolysis | negative regulation of cell migration | negative regulation of cellular metabolic process | response to peptide hormone | tissue development | negative regulation of cell motility | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | cellular component organization | response to stimulus | enzyme inhibitor activity | response to stress | regulation of cell proliferation | response to peptide | secretion by cell | extracellular matrix organization | negative regulation of metabolic process | protein modification process | cartilage development | macromolecule modification | molecular function regulator | response to nitrogen compound | system development | nitrogen compound metabolic process | regulation of signal transduction | multicellular organism development | negative regulation of catalytic activity | regulation of peptidase activity | inflammatory response to wounding | regulation of catalytic activity | negative regulation of peptidase activity | connective tissue replacement involved in inflammatory response wound healing | wound healing | negative regulation of metallopeptidase activity | regulation of nitrogen compound metabolic process | regulation of cell migration | cytokine-mediated signaling pathway | vesicle-mediated transport | regulation of cellular component movement | cellular response to cytokine stimulus | regulation of cellular protein metabolic process | regulated exocytosis | cell communication | regulation of cellular metabolic process | inflammatory response | regulation of protein metabolic process | positive regulation of cell proliferation | regulation of locomotion | wound healing involved in inflammatory response | regulation of signaling receptor activity | receptor regulator activity | protein metabolic process | response to organic substance | response to wounding | anatomical structure development | cell surface receptor signaling pathway | growth factor activity | metabolic process | regulation of protein catabolic process | negative regulation of programmed cell death | receptor ligand activity | cytokine activity | organic substance metabolic process | connective tissue development | animal organ development | negative regulation of cellular protein metabolic process | negative regulation of cellular component movement | cell activation | negative regulation of protein catabolic process | negative regulation of protein metabolic process | regulation of cell communication | negative regulation of molecular function | signaling | metalloendopeptidase inhibitor activity | peptidase inhibitor activity | cellular protein metabolic process | enzyme regulator activity | regulation of endopeptidase activity | regulation of developmental process | developmental process | cellular protein modification process | response to organonitrogen compound | negative regulation of hydrolase activity | skeletal system development | cellular metabolic process | cellular response to organic substance | regulation of cell death | negative regulation of trophoblast cell migration | negative regulation of cell death | aging | negative regulation of locomotion | extracellular matrix disassembly | signal transduction | regulation of signaling | negative regulation of endopeptidase activity | post-translational protein modification | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

secretory granule | intracellular membrane-bounded organelle | extracellular matrix | basement membrane | cytoplasmic vesicle | cell | cytoplasmic vesicle lumen | cytoplasm | collagen-containing extracellular matrix | intracellular organelle | endoplasmic reticulum | platelet alpha granule | secretory vesicle | endomembrane system | vesicle | endoplasmic reticulum lumen | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | membrane-enclosed lumen | secretory granule lumen | intracellular vesicle | intracellular | platelet alpha granule lumen | vesicle lumen