QuickView for Timp2 (gene)

Gene Symbol:

TIMP2 Homo sapiens

Full name:

TIMP metallopeptidase inhibitor 2

Synonyms:

CSC-21K, DDC8, metalloproteinase inhibitor 2, testicular secretory protein Li 57, tissue inhibitor of metalloproteinases 2

Genomic Location:

Chr 17: 74360654-74433067

Description:

This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in i...

View Full Description

This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTTGCAG_MIR518A2 ,  RSRFC4_01 ,  CAGGTCC_MIR492 ,  YTATTTTNR_MEF2_02 ,  WGTTNNNNNAAA_UNKNOWN ,  TTGCACT_MIR130A_MIR301_MIR130B ,  CTAWWWATA_RSRFC4_Q2 ,  MEF2_02 ,  MEF2_01 ,  GTTTGTT_MIR495 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  HMEF2_Q6 ,  MEF2_03 ,  AGGGCAG_MIR18A ,  TGCACTT_MIR519C_MIR519B_MIR519A

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-214 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-495 ,  Predicted Gene Targets for miR-505 ,  Predicted Gene Targets for miR-544

Cytogenetic Map:

17q25.3

search → result