QuickView for Tip-40 (gene)

Gene Symbol:

PARD6A Homo sapiens

Full name:

par-6 family cell polarity regulator alpha

Synonyms:

PAR-6A, PAR6, PAR6C, PAR6alpha, TAX40, TIP-40, partitioning defective 6 homolog alpha, PAR-6 alpha, Tax-interacting protein 40, par-6 partitioning defective 6 homolog alpha, partitioning-defective protein 6, tax interaction protein 40

Genomic Location:

Chr 16: 66252352-66254182

Description:

This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to...

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This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  CREBP1CJUN_01 ,  YRTCANNRCGC_UNKNOWN ,  HP1SITEFACTOR_Q6 ,  TGACCTY_ERR1_Q2 ,  CREB_Q3 ,  TGAYRTCA_ATF3_Q6 ,  ATF_B ,  E47_02 ,  GGGCGGR_SP1_Q6 ,  AREB6_03 ,  RNGTGGGC_UNKNOWN ,  AP2REP_01 ,  ATF1_Q6 ,  TGACGTCA_ATF3_Q6 ,  SP1_Q6_01 ,  ACAWYAAAG_UNKNOWN ,  CREB_01 ,  LMO2COM_01

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Cytogenetic Map:

16q22.1

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