QuickView for Tip48 (gene)

Gene Symbol:

RUVBL2 Homo sapiens

Full name:

RuvB like AAA ATPase 2

Synonyms:

CGI-46, ECP-51, ECP51, INO80J, REPTIN, RVB2, TAP54-beta, TIH2, TIP48, TIP49B, ruvB-like 2, 48 kDa TATA box-binding protein-interacting protein, 48 kDa TBP-interacting protein, 51 kDa erythrocyte cytosolic protein, INO80 complex subunit J, RuvB (E coli homolog)-like 2, TIP60-associated protein 54-beta, erythrocyte cytosolic protein, 51-KD, repressing pontin 52, reptin52 protein

Genomic Location:

Chr 19: 54188968-54210994

Description:

This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chro...

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This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Schizosaccharomyces pombe ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CMYB_01 ,  CEBPA_01 ,  CEBP_Q2_01 ,  XBP1_01 ,  CEBP_Q2 ,  CEBPB_01 ,  GR_Q6 ,  GGAANCGGAANY_UNKNOWN ,  CEBPB_02 ,  CEBP_Q3 ,  CTGCAGY_UNKNOWN ,  HIF1_Q3

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Cytogenetic Map:

19q13.33

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