Name: | tizanidine |
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PubChem Compound ID: | 114869 |
Molecular formula: | C9H9Cl2N5S |
Molecular weight: | 290.173 g/mol |
Synonyms: |
5-Chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole monohydrochloride; DS-103282 ch; Sirdalud; Ternelin; 51322-75-9; 5-Chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole hydrochloride; Tizanidine hydrochloride (JP15/USAN); AN-021A; Zanaflex; D00776.
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Name: | tizanidine |
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Name (isomeric): | DB00697 |
Drug Type: | small molecule |
Synonyms: |
Tizanidine Hcl; Tizanidina [INN-Spanish]; Tizanidinum [INN-Latin]
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Brand: | Sirdalud, Zanaflex, Ternelin |
Category: | Parasympatholytics, Adrenergic alpha-Agonists, Muscle Relaxants, Central, Muscle Relaxants, Analgesics, Anticonvulsants, Skeletal Muscle Relaxants |
CAS number: | 51322-75-9 |
Indication: | For the management of increased muscle tone associated with spasticity |
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Pharmacology: |
Tizanidine is a short-acting drug for the management of spasticity. Tizanidine is an agonist at a2-adrenergic receptor sites and presumably reduces spasticity by increasing presynaptic inhibition of motor neurons. In animal models, tizanidine has no direct effect on skeletal muscle fibers or the neuromuscular junction, and no major effect on monosy...
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Mechanism of Action: | Tizanidine reduces spasticity by increasing presynaptic inhibition of motor neurons through agonist action at a2-adrenergic receptor sites. |
Protein binding: | 30% |
Route of elimination: | Approximately 95% of an administered dose is metabolized. |
Half Life: | 2.5 hours |
Affected organisms: | Humans and other mammals |
Drug interaction: |
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