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QuickView for Tjp1 (gene)


Gene Symbol:
TJP1 Homo sapiens Homo sapiens
Full name:
tight junction protein 1
Synonyms:
ZO-1, tight junction protein ZO-1, zona occludens 1, zonula occludens 1 protein
Genomic Location:
Chr 15: 27779648-27901998
Description:
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, and acts as a tight junction adaptor protein that also regulates adherens junctions. Tight junctions regulate the movement of ions and macromolecules between endothelial and epithelial cells. The multidomain structure of this scaffold protein, includi...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Canis lupus familiaris Bos taurus Gallus gallus Pan troglodytes Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
miRNA binding sites
(Source: miRecords):
Cytogenetic Map:
chr 15
15q13.1





GO Molecular Function

cadherin binding | cell adhesion molecule binding | protein binding | calmodulin binding

GO Biological Process

intracellular signal transduction | endothelial cell development | cell differentiation | endothelial cell differentiation | cellular process | tissue development | cell junction assembly | regulation of cellular process | regulation of bicellular tight junction assembly | epithelium development | cellular component organization | response to stimulus | epithelial cell development | cellular component assembly | cell-cell signaling | endothelium development | hippo signaling | establishment of endothelial barrier | cell communication | establishment of endothelial intestinal barrier | anatomical structure development | cell-cell junction assembly | signaling | cell development | cell-cell signaling involved in cell-cell junction organization | developmental process | regulation of cell junction assembly | epithelial cell differentiation | regulation of cellular component organization | signal transduction | cell-cell junction organization

GO Cellular Component

occluding junction | adherens junction | cell | cytoplasm | intracellular organelle | actin cytoskeleton | apical part of cell | cell-cell adherens junction | cell-cell junction | protein-containing complex | cell projection | plasma membrane | podosome | gap junction | apical junction complex | organelle | cell periphery | bicellular tight junction | basolateral plasma membrane | cytosol | cytoskeleton | intracellular | cell junction | membrane