QuickView for Tjp2 (gene)

Gene Symbol:

TJP2 Homo sapiens

Full name:

tight junction protein 2

Synonyms:

C9DUPq21.11, DFNA51, DUP9q21.11, PFIC4, X104, ZO2, tight junction protein ZO-2, Friedreich ataxia region gene X104 (tight junction protein ZO-2), zona occludens 2, zonula occludens protein 2

Genomic Location:

Chr 9: 70978909-71059940

Description:

This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercho...

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This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFAT_Q4_01 ,  TGGAAA_NFAT_Q4_01 ,  TTANTCA_UNKNOWN ,  P53_DECAMER_Q2 ,  FOXO4_01 ,  YATTNATC_UNKNOWN ,  CAGGTA_AREB6_01 ,  P53_02 ,  MGGAAGTG_GABP_B ,  GTGCCTT_MIR506 ,  TTGTTT_FOXO4_01 ,  TGACAGNY_MEIS1_01 ,  CP2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-124a

miRNA binding sites
(Source: miRecords):

hsa-miR-124 Targeted Genes

Cytogenetic Map:

9q21.11

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