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QuickView for Tnfaip1 (gene)


Gene Symbol:
TNFAIP1 Homo sapiens Homo sapiens
Full name:
TNF alpha induced protein 1
Synonyms:
B12, B61, BTBD34, EDP1, hBACURD2, BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2, BTB/POZ domain-containing protein TNFAIP1, tumor necrosis factor, alpha induced protein 1, tumor necrosis factor, alpha-induced protein 1 (endothelial)
Genomic Location:
Chr 17: 23686913-23698160
Description:
This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
miRNA binding sites
(Source: miRecords):
Cytogenetic Map:
chr 17
17q11.2


Transcripts Names
NM_021137
XM_017024993
Protein Names
Q5TZQ1
Q13829



GO Molecular Function

GTPase binding | Rho GTPase binding | enzyme binding | Ras GTPase binding | catalytic activity | protein domain specific binding | ubiquitin-like protein transferase activity | identical protein binding | protein binding | ubiquitin-protein transferase activity | transferase activity | small GTPase binding | GTP-Rho binding

GO Biological Process

protein homooligomerization | positive regulation of macromolecule biosynthetic process | actin filament-based process | cell motility | proteolysis | actin filament bundle organization | actin cytoskeleton organization | negative regulation of cellular process | regulation of DNA replication | positive regulation of cellular biosynthetic process | cellular process | organic substance catabolic process | localization | proteolysis involved in cellular protein catabolic process | negative regulation of signaling | positive regulation of nitrogen compound metabolic process | regulation of cellular process | regulation of metabolic process | catabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | cellular component organization | response to stimulus | programmed cell death | supramolecular fiber organization | cellular protein catabolic process | cellular nitrogen compound metabolic process | proteasomal protein catabolic process | cellular component assembly | protein modification process | cellular biosynthetic process | macromolecule modification | locomotion | apoptotic process | nitrogen compound metabolic process | regulation of signal transduction | cell migration | positive regulation of DNA replication | actin filament organization | protein complex oligomerization | regulation of small GTPase mediated signal transduction | protein catabolic process | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | actin filament bundle assembly | regulation of Rho protein signal transduction | biosynthetic process | actomyosin structure organization | regulation of cellular metabolic process | contractile actin filament bundle assembly | proteasome-mediated ubiquitin-dependent protein catabolic process | protein-containing complex assembly | protein metabolic process | protein ubiquitination | DNA metabolic process | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | cellular macromolecule catabolic process | metabolic process | ubiquitin-protein transferase activity | immune response | negative regulation of Rho protein signal transduction | nucleobase-containing compound metabolic process | organic substance metabolic process | cell death | negative regulation of small GTPase mediated signal transduction | negative regulation of Ras protein signal transduction | protein modification by small protein conjugation or removal | cytoskeleton organization | ubiquitin-dependent protein catabolic process | organonitrogen compound catabolic process | regulation of cell communication | negative regulation of signal transduction | cellular protein metabolic process | regulation of Ras protein signal transduction | cellular macromolecule biosynthetic process | stress fiber assembly | positive regulation of DNA metabolic process | organelle organization | cellular protein modification process | heterocycle metabolic process | positive regulation of metabolic process | immune system process | cellular metabolic process | modification-dependent protein catabolic process | DNA replication | regulation of signaling | macromolecule metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | catalytic complex | cytoplasmic vesicle | cell | nuclear lumen | Cul3-RING ubiquitin ligase complex | nucleolus | cytoplasm | intracellular organelle | ubiquitin ligase complex | protein-containing complex | endomembrane system | vesicle | transferase complex | endosome | cullin-RING ubiquitin ligase complex | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular vesicle | intracellular