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QuickView for Tnfaip3 (gene)


Gene Symbol:
TNFAIP3 Homo sapiens Homo sapiens
Full name:
TNF alpha induced protein 3
Synonyms:
A20, AISBL, OTUD7C, TNFA1P2, tumor necrosis factor alpha-induced protein 3, OTU domain-containing protein 7C, putative DNA-binding protein A20, tumor necrosis factor inducible protein A20, tumor necrosis factor, alpha induced protein 3, zinc finger protein A20
Genomic Location:
Chr 6: 138230274-138246142
Description:
This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitina...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Cytogenetic Map:
chr 6
6q23.3





GO Molecular Function

protein self-association | kinase binding | K63-linked polyubiquitin modification-dependent protein binding | cation binding | enzyme binding | nucleic acid binding | thiol-dependent ubiquitinyl hydrolase activity | hydrolase activity | ubiquitin binding | cysteine-type peptidase activity | catalytic activity | polyubiquitin modification-dependent protein binding | ubiquitin-like protein transferase activity | modification-dependent protein binding | DNA binding | identical protein binding | ubiquitin-like protein binding | thiol-dependent ubiquitin-specific protease activity | ion binding | organic cyclic compound binding | Lys63-specific deubiquitinase activity | protein binding | ubiquitinyl hydrolase activity | zinc ion binding | ubiquitin-protein transferase activity | transferase activity | transition metal ion binding | protease binding | metal ion binding | heterocyclic compound binding | peptidase activity

GO Biological Process

positive regulation of immune response | protein modification by small protein removal | leukocyte homeostasis | negative regulation of leukocyte activation | nucleotide-binding oligomerization domain containing signaling pathway | negative regulation of phosphorylation | regulation of interleukin-1 beta production | negative regulation of immune system process | regulation of B cell activation | cell motility | immune response-regulating signaling pathway | response to lipopolysaccharide | negative regulation of type I interferon production | intracellular signal transduction | proteolysis | protein localization to vacuole | regulation of programmed cell death | establishment of localization | regulation of immune system process | negative regulation of cellular process | negative regulation of kinase activity | positive regulation of developmental process | positive regulation of epithelial cell proliferation | negative regulation of tissue remodeling | regulation of toll-like receptor 3 signaling pathway | defense response | tolerance induction to lipopolysaccharide | positive regulation of protein catabolic process | response to drug | negative regulation of protein phosphorylation | negative regulation of chronic inflammatory response | negative regulation of toll-like receptor 4 signaling pathway | response to antibiotic | regulation of toll-like receptor 4 signaling pathway | regulation of bone remodeling | innate immune response-activating signal transduction | cellular process | organic substance catabolic process | negative regulation of inflammatory response | localization | proteolysis involved in cellular protein catabolic process | negative regulation of signaling | tolerance induction | immune system development | negative regulation of innate immune response | macromolecule localization | regulation of CD40 signaling pathway | regulation of response to cytokine stimulus | negative regulation of apoptotic process | regulation of defense response to virus | regulation of hepatocyte proliferation | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | protein K11-linked deubiquitination | response to inorganic substance | negative regulation of cellular metabolic process | negative regulation of osteoclast proliferation | negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway | negative regulation of apoptotic signaling pathway | response to hydrogen peroxide | regulation of angiogenesis | regulation of immune response | regulation of cellular process | negative regulation of interleukin-1 production | regulation of apoptotic process | negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway | cellular response to lipid | regulation of metabolic process | catabolic process | cellular response to molecule of bacterial origin | negative regulation of tumor necrosis factor production | negative regulation of toll-like receptor 5 signaling pathway | positive regulation of cellular protein metabolic process | negative regulation of bone resorption | cellular component organization | protein deubiquitination | negative regulation of toll-like receptor signaling pathway | thiol-dependent ubiquitinyl hydrolase activity | positive regulation of cellular protein catabolic process | regulation of type I interferon production | regulation of vasculature development | response to stimulus | negative regulation of epithelial cell apoptotic process | positive regulation of innate immune response | positive regulation of immune system process | positive regulation of protein metabolic process | regulation of cellular protein catabolic process | response to stress | negative regulation of tumor necrosis factor superfamily cytokine production | negative regulation of lymphocyte activation | negative regulation of protein kinase activity | negative regulation of CD40 signaling pathway | regulation of cell proliferation | regulation of protein ubiquitination | response to peptide | response to muramyl dipeptide | programmed cell death | activation of innate immune response | cellular protein catabolic process | cellular localization | response to molecule of bacterial origin | cellular response to toxic substance | protein K33-linked deubiquitination | protein K48-linked deubiquitination | immune response-activating signal transduction | negative regulation of metabolic process | cellular component assembly | regulation of wound healing | protein modification process | macromolecule modification | negative regulation of toll-like receptor 2 signaling pathway | cysteine-type peptidase activity | regulation of nucleic acid-templated transcription | negative regulation of NF-kappaB transcription factor activity | locomotion | response to nitrogen compound | apoptotic process | response to external biotic stimulus | system development | regulation of cyclin-dependent protein serine/threonine kinase activity | nitrogen compound metabolic process | regulation of signal transduction | pattern recognition receptor signaling pathway | negative regulation of phosphate metabolic process | cellular response to antibiotic | negative regulation of interleukin-6 production | multicellular organism development | negative regulation of catalytic activity | cell migration | regulation of toll-like receptor signaling pathway | protein complex oligomerization | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | cellular response to oxidative stress | regulation of phosphorylation | regulation of gene expression | regulation of extrinsic apoptotic signaling pathway | cellular response to stress | response to lipid | protein catabolic process | negative regulation of cyclin-dependent protein serine/threonine kinase activity | negative regulation of cytokine production | positive regulation of cellular metabolic process | regulation of lymphocyte activation | negative regulation of smooth muscle cell proliferation | regulation of germinal center formation | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | negative regulation of DNA-binding transcription factor activity | negative regulation of protein serine/threonine kinase activity | regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway | regulation of endothelial cell apoptotic process | response to oxidative stress | negative regulation of toll-like receptor 3 signaling pathway | B cell homeostasis | protein localization to organelle | negative regulation of extrinsic apoptotic signaling pathway | homeostasis of number of cells | regulation of cellular protein metabolic process | negative regulation of immune response | thiol-dependent ubiquitin-specific protease activity | response to toxic substance | regulation of apoptotic signaling pathway | regulation of epithelial cell apoptotic process | regulation of tumor necrosis factor production | cellular response to drug | response to bacterium | regulation of interleukin-1 production | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | lymphocyte homeostasis | negative regulation of cell activation | inflammatory response | regulation of tumor necrosis factor-mediated signaling pathway | regulation of protein metabolic process | positive regulation of signal transduction | negative regulation of interleukin-2 production | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of cytokine-mediated signaling pathway | regulation of RNA metabolic process | negative regulation of protein ubiquitination | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | regulation of nucleotide-binding oligomerization domain containing signaling pathway | Lys63-specific deubiquitinase activity | negative regulation of B cell activation | protein polyubiquitination | negative regulation of cyclin-dependent protein kinase activity | protein-containing complex assembly | activation of immune response | nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | protein metabolic process | protein K63-linked deubiquitination | protein deubiquitination involved in ubiquitin-dependent protein catabolic process | response to organic substance | regulation of innate immune response | protein ubiquitination | regulation of kinase activity | regulation of lipopolysaccharide-mediated signaling pathway | regulation of animal organ morphogenesis | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | cellular macromolecule catabolic process | establishment of protein localization to organelle | anatomical structure development | regulation of chronic inflammatory response | metabolic process | negative regulation of I-kappaB kinase/NF-kappaB signaling | ubiquitin-protein transferase activity | regulation of protein catabolic process | regulation of adaptive immune response | negative regulation of leukocyte proliferation | regulation of RNA biosynthetic process | negative regulation of programmed cell death | cellular protein localization | regulation of bone resorption | regulation of tissue remodeling | cellular response to hydrogen peroxide | cellular response to reactive oxygen species | organic substance metabolic process | cell death | response to reactive oxygen species | negative regulation of cellular protein metabolic process | regulation of cell activation | protein modification by small protein conjugation or removal | regulation of Wnt signaling pathway | regulation of phosphate metabolic process | establishment of protein localization to vacuole | cytoskeleton organization | establishment of protein localization | intracellular receptor signaling pathway | ubiquitin-dependent protein catabolic process | negative regulation of cell cycle | negative regulation of protein metabolic process | organonitrogen compound catabolic process | regulation of response to wounding | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | regulation of extrinsic apoptotic signaling pathway via death domain receptors | signaling | regulation of transcription, DNA-templated | protein localization | regulation of epithelial cell proliferation | cellular protein metabolic process | regulation of cytokine production | cellular macromolecule localization | response to biotic stimulus | regulation of developmental process | developmental process | organelle organization | cellular protein modification process | negative regulation of interleukin-1 beta production | protein K29-linked deubiquitination | negative regulation of cell proliferation | response to organonitrogen compound | regulation of defense response to virus by host | regulation of vascular wound healing | positive regulation of hepatocyte proliferation | protein K48-linked ubiquitination | negative regulation of bone remodeling | positive regulation of metabolic process | immune system process | positive regulation of Wnt signaling pathway | cellular metabolic process | negative regulation of lipopolysaccharide-mediated signaling pathway | peptidase activity | cellular response to organic substance | regulation of cell death | regulation of smooth muscle cell proliferation | modification-dependent protein catabolic process | negative regulation of cell death | regulation of interleukin-6 production | regulation of inflammatory response | B-1 B cell homeostasis | regulation of I-kappaB kinase/NF-kappaB signaling | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | negative regulation of endothelial cell apoptotic process | cellular response to lipopolysaccharide | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | vacuole | vesicle | extracellular exosome | lytic vacuole | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | lysosome | extracellular space | cytosol | intracellular