QuickView for Tnni1 (gene)

Gene Symbol:

TNNI1 Homo sapiens

Full name:

troponin I1, slow skeletal type

Synonyms:

SSTNI, TNN1, troponin I, slow skeletal muscle, troponin I type 1 (skeletal, slow), troponin I, slow-twitch isoform

Genomic Location:

Chr 1: 199639518-199657497

Description:

Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-...

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Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

PR_Q2 ,  YATGNWAAT_OCT_C ,  YTATTTTNR_MEF2_02 ,  CATTGTYY_SOX9_B1 ,  GCANCTGNY_MYOD_Q6 ,  GGGACCA_MIR133A_MIR133B ,  RSRFC4_Q2 ,  ZIC3_01 ,  COUP_01 ,  MYB_Q5_01 ,  CTAWWWATA_RSRFC4_Q2 ,  TGACCTY_ERR1_Q2 ,  TAAWWATAG_RSRFC4_Q2 ,  MEF2_02 ,  AR_Q6 ,  GGATTA_PITX2_Q2 ,  CAGGTG_E12_Q6 ,  DR1_Q3 ,  GR_Q6 ,  NF1_Q6 ,  TGCCAAR_NF1_Q6 ,  AREB6_03 ,  MYB_Q6 ,  POU3F2_02 ,  SREBP_Q3 ,  WCAANNNYCAG_UNKNOWN ,  CDC5_01 ,  PAX4_03 ,  TGACCTTG_SF1_Q6 ,  SF1_Q6 ,  MYB_Q3

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-133

Cytogenetic Map:

1q32.1

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