QuickView for Tob1 (gene)

Gene Symbol:

TOB1 Homo sapiens

Full name:

transducer of ERBB2, 1

Synonyms:

APRO5, APRO6, PIG49, TOB, TROB, TROB1, protein Tob1, proliferation-inducing gene 49, transducer of erbB-2 1

Genomic Location:

Chr 17: 46294583-46296412

Description:

This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants.

This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Danio rerio ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

POU6F1_01 ,  OCT1_07 ,  RTAAACA_FREAC2_01 ,  HNF3ALPHA_Q6 ,  AP1_C ,  TGANTCA_AP1_C ,  CEBPA_01 ,  GATA1_03 ,  MZF1_01 ,  FOXJ2_02 ,  FOX_Q2 ,  HFH3_01 ,  TGANNYRGCA_TCF11MAFG_01 ,  HOXA4_Q2 ,  TTTTGAG_MIR373 ,  POU3F2_01 ,  TTGCWCAAY_CEBPB_02 ,  GATA_C ,  NKX3A_01 ,  GCAAGGA_MIR502 ,  FOXD3_01 ,  HFH1_01 ,  CIZ_01 ,  EVI1_04 ,  CEBP_Q2_01 ,  TACTTGA_MIR26A_MIR26B ,  STAT6_01 ,  GATAAGR_GATA_C ,  HNF1_C ,  CTTTGA_LEF1_Q2 ,  PBX1_01 ,  TTAYRTAA_E4BP4_01 ,  WHN_B ,  GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367 ,  GTACAGG_MIR486 ,  OSF2_Q6 ,  GGGAGGRR_MAZ_Q6 ,  TATAAA_TATA_01 ,  CEBP_Q2 ,  NFE2_01 ,  CEBPB_01 ,  AP1_Q6_01 ,  CDP_02 ,  DBP_Q6 ,  PAX4_02 ,  YYCATTCAWW_UNKNOWN ,  CDX2_Q5 ,  LHX3_01 ,  EVI1_02 ,  TST1_01 ,  AP1FJ_Q2 ,  TATA_C ,  HNF3_Q6 ,  SP3_Q3 ,  EVI1_05 ,  ATTCTTT_MIR186 ,  HNF3B_01 ,  CATRRAGC_UNKNOWN ,  ATGTTAA_MIR302C ,  TGCTGAY_UNKNOWN ,  STAT5A_03 ,  CREBP1_01 ,  CEBPB_02 ,  LMO2COM_02 ,  YKACATTT_UNKNOWN ,  NKX61_01 ,  ACTGAAA_MIR30A3P_MIR30E3P ,  CTTTAAR_UNKNOWN ,  AAAGACA_MIR511 ,  TGTTTGY_HNF3_Q6 ,  HFH8_01 ,  SOX5_01 ,  HLF_01 ,  TTGCCAA_MIR182 ,  FREAC2_01 ,  CEBP_Q3 ,  MTF1_Q4 ,  TTGTTT_FOXO4_01 ,  CHOP_01 ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  GATA4_Q3 ,  TEF_Q6 ,  T3R_Q6 ,  AP1_Q2 ,  CTTTGT_LEF1_Q2 ,  CAGCTG_AP4_Q5 ,  BRN2_01 ,  AACTTT_UNKNOWN ,  YNGTTNNNATT_UNKNOWN ,  PAX2_02 ,  AP1_Q4_01 ,  EVI1_01 ,  HNF6_Q6 ,  GGGTGGRR_PAX4_03 ,  AAGCACA_MIR218 ,  MYB_Q3

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-30-3p ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-409-3p ,  Predicted Gene Targets for miR-486

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Cytogenetic Map:

17q21.33

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