QuickView for TonEBP (gene)

Gene Symbol:

NFAT5 Homo sapiens

Full name:

nuclear factor of activated T cells 5

Synonyms:

NF-AT5, NFATL1, NFATZ, OREBP, TONEBP, nuclear factor of activated T-cells 5, NFAT-like protein 1, T-cell transcription factor NFAT5, TonE-binding protein, glutamine rich protein H65, nuclear factor of activated T-cells 5, tonicity-responsive, osmotic response element-binding protein, tonicity-responsive enhancer-binding protein

Genomic Location:

Chr 16: 68156498-68296054

Description:

The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this prot...

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The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFAT_Q4_01 ,  TGGAAA_NFAT_Q4_01 ,  ACTGTAG_MIR139 ,  STAT4_01 ,  CEBPA_01 ,  ACACTCC_MIR122A ,  TTANTCA_UNKNOWN ,  RYTTCCTG_ETS2_B ,  GGGATGC_MIR3245P ,  RSRFC4_01 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  YTATTTTNR_MEF2_02 ,  STAT6_02 ,  GGGACCA_MIR133A_MIR133B ,  RSRFC4_Q2 ,  MEF2_04 ,  AP2GAMMA_01 ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  NFKAPPAB_01 ,  AMEF2_Q6 ,  ACTTTAT_MIR1425P ,  SREBP1_Q6 ,  IRF1_Q6 ,  AP2ALPHA_01 ,  CTAWWWATA_RSRFC4_Q2 ,  MAF_Q6 ,  TAAWWATAG_RSRFC4_Q2 ,  GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367 ,  GTACAGG_MIR486 ,  NFKAPPAB65_01 ,  MEF2_02 ,  AGCATTA_MIR155 ,  DBP_Q6 ,  TCTGATA_MIR361 ,  TAATGTG_MIR323 ,  GCACCTT_MIR18A_MIR18B ,  LFA1_Q6 ,  SP1_Q4_01 ,  ATTCTTT_MIR186 ,  GTTTGTT_MIR495 ,  ATGCTGC_MIR103_MIR107 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  GGGCGGR_SP1_Q6 ,  ATGTTAA_MIR302C ,  ACTGCCT_MIR34B ,  AGGTGCA_MIR500 ,  AP2_Q3 ,  SP1_Q6 ,  GTGCCTT_MIR506 ,  MTF1_Q4 ,  MEF2_03 ,  RGAGGAARY_PU1_Q6 ,  CREL_01 ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  RNTCANNRNNYNATTW_UNKNOWN ,  RCGCANGCGY_NRF1_Q6 ,  NFKB_Q6_01 ,  CTGTTAC_MIR194 ,  SP1_Q6_01 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  BRN2_01 ,  AACTTT_UNKNOWN ,  ACAGGGT_MIR10A_MIR10B ,  ATGAAGG_MIR205 ,  NFKB_Q6 ,  NFKB_C ,  CCACACA_MIR147 ,  SP1_Q2_01 ,  GGGNNTTTCC_NFKB_Q6_01 ,  TCCAGAG_MIR518C ,  CTCCAAG_MIR432

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-10 ,  Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-122a ,  Predicted Gene Targets for miR-132 ,  Predicted Gene Targets for miR-133 ,  Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-139 ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-18 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-194 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-204 ,  Predicted Gene Targets for miR-205 ,  Predicted Gene Targets for miR-221 ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-324-5p ,  Predicted Gene Targets for miR-34b ,  Predicted Gene Targets for miR-361 ,  Predicted Gene Targets for miR-379 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-494 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-155 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-31 ,  Predicted Gene Targets for miR-376c ,  Predicted Gene Targets for miR-380-5p ,  Predicted Gene Targets for miR-384 ,  Predicted Gene Targets for miR-410 ,  Predicted Gene Targets for miR-486 ,  Predicted Gene Targets for miR-495 ,  Predicted Gene Targets for miR-500

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Cytogenetic Map:

16q22.1

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