QuickView for Tph2 (gene)

Gene Symbol:

TPH2 Homo sapiens

Full name:

tryptophan hydroxylase 2

Synonyms:

ADHD7, NTPH, tryptophan 5-hydroxylase 2, neuronal tryptophan hydroxylase, tryptophan 5-monooxygenase 2

Genomic Location:

Chr 12: 70618893-70712488

Description:

This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.

This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TAL1ALPHAE47_01 ,  SRY_01 ,  TATAAA_TATA_01 ,  LMO2COM_02 ,  YKACATTT_UNKNOWN ,  GATA6_01 ,  POU1F1_Q6 ,  TTGTTT_FOXO4_01 ,  GATA1_05 ,  TAL1BETAITF2_01 ,  BRN2_01

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Cytogenetic Map:

12q21.1

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