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QuickView for Transcription elongation factor, TFIIS (biogroup)
- Description:
- Transcription elongation factor IIS (TFIIS) is a component of RNA polymerase II preinitiation complexes, and is required for preinitiation complex assembly and stability. The association of TFIIS with a promoter depends on functional preinitiation complex components including Mediator and the SAGA complex. TFIIS is composed of three domains: domain 1 forms a 4-helical bundle that appears to bind certain initiation factors; domain 2 forms a 3-helical bundle and is required for Pol II binding; domain 3 forms a zinc ribbon and is essential for stimulation of RNA cleavage.
- Taxonomy/Path:
- InterPro : Transcription elongation factor, IIS-type / Transcription elongation factor, TFIIS
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