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QuickView for Treprostinil (compound)

Name: treprostinil
PubChem Compound ID: 11246284
Molecular formula: C23H34O5
Molecular weight: 390.513 g/mol
Name: treprostinil
Name (isomeric): DB00374
Drug Type: small molecule
Brand: Viveta, Remodulin
Category: Vitamin K antagonists, Antihypertensive Agents, Antithrombotic Agents
CAS number: 81846-19-7
Indication: For use as a continuous subcutaneous infusion or intravenous infusion (for those not able to tolerate a subcutaneous infusion) for the treatment of pulmonary arterial hypertension in patients with NYHA Class II-IV symptoms to diminish symptoms associated with exercise.
Pulmonary arterial hypertension (PAH) is a disease in which blood pressure is abnormally high in the arteries between the heart and lungs. PAH is characterized by symptoms of shortness of breath during physical exertion. The condition can ultimately lead to heart failure. Treprostinil is a potent oral antiplatelet agent. The major pharmacologic act...
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Mechanism of Action:
The major pharmacological actions of treprostinil are direct vasodilation of pulmonary and systemic arterial vascular beds and inhibition of platelet aggregation. In addition to treprostinil's direct vasodilatory effects, it also inhibits inflammatory cytokine. As a synthetic analogue of prostacyclin, it binds to the prostacyclin receptor, which su...
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Absorption: Relatively rapid and complete after subcutaneous infusion, with an absolute bioavailability approximately 100%. In patients with mild (n=4) or moderate (n=5) hepatic insufficiency and portopulmonary hypertension following a subcutaneous dose of 10 ng per kg of body weight per min for 150 mins the AUC 0-∞ was increased 3-fold and 5-fold respectively.
Protein binding: Human plasma protein binding is approximately 91% in in vitro concentrations ranging from 330 to 10,000 µ/L.
Biotransformation: Substantially metabolized by the liver, but the precise enzymes responsible are unknown. Five metabolites have been described (HU1 through HU5) however, the biological activity and metabolic fate of these are unknown. The chemical structure of HU1 is unknown. The metabolite HU5 is the glucuronide conjugate of treprostinil. The other metabolites are formed by oxidation of the 3-hydroxyoctyl side chain (HU2) and subsequent additional oxidation (HU3) or dehydration (HU4). Study results of in vitro human hepatic cytochrome P450 demonstrates that treprostinil does not inhibit CYP-1A2, 2C9, 2C19, 2D6, 2E1, or 3A. Whether treprostinil induces these enzymes has not been studied.
Half Life: Terminal elimination half-life is approximately 2 to 4 hours. Plasma half-life is 34 and 85 minutes for intravenous and subcutaneous infusion of the drug, respectively.
Toxicity: Symptoms of overdose are extensions of its dose-limiting pharmacologic effects and include flushing, headache, hypotension, nausea, vomiting, and diarrhea. Most events were self-limiting and resolved with reduction or withholding of treprostinil.
Affected organisms: Humans and other mammals
Drug interaction:
PhenoxybenzamineAdditive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
HydrochlorothiazideAdditive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
GuanabenzAdditive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
BisoprololAdditive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
LosartanAdditive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
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