Name: | Tretinoin |
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PubChem Compound ID: | 10335106 |
Description: | An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE). |
Molecular formula: | C20H30O2 |
Molecular weight: | 302.451 g/mol |
Name: | Tretinoin |
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Name (isomeric): | DB00755 |
Drug Type: | small molecule |
Description: | An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE). |
Synonyms: |
Retionic Acid; All Trans-Retinoic Acid; All Trans Retinoic Acid; beta-Retinoic Acid; ATRA
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Brand: | Airol, Claravis, Amnesteem, Tri-Luma, Lsotretinoin, Stieva-a Forte, Accutane, Vitinoin, Aknoten, Sotret, Eudyna, Solage, Atra-IV, Aknefug, Stieva-A, Aberel, Dermairol, Retisol-A |
Category: | Keratolytic Agents, Cell Stimulants and Proliferants, Antineoplastic Agents |
CAS number: | 302-79-4 |
Indication: | For the the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant); For the topical treatment of acne vulgaris, flat warts and other skin conditions (psoriasis, ichthyosis congenita, icthyosis vulgaris, lamellar icthyosis, keratosis palmaris et plantaris, epidermolytic hyperkeratosis, senile comedones, senile keratosis, keratosis follicularis (Darier's disease), and basal cell carcinomas.); For palliative therapy to improve fine wrinkling, mottled hyperpigmentation, roughness associated with photodamage. |
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Pharmacology: |
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). Retinoids such as tretinoin are important regulators of cell reproduction, proliferation, and differentiation and are used to treat acne and photodamaged skin and to manage keratinization disorders such as ichthyosis and kerat...
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Mechanism of Action: |
Tretinoin binds to alpha, beta, and gamma retinoic acid receptors (RARs). RAR-alpha and RAR-beta have been associated with the development of acute promyelocytic leukemia and squamous cell cancers, respectively. RAR-gamma is associated with retinoid effects on mucocutaneous tissues and bone. Although the exact mechanism of action of tretinoin is un...
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Absorption: | 1-31% (topical) |
Protein binding: | > 95% |
Biotransformation: | Hepatic |
Half Life: | 0.5-2 hours |
Affected organisms: | Humans and other mammals |
Drug interaction: |
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