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QuickView for Trimethadione (compound)

Summary
General Info

PubChem

PubChem Compound 5576

PubChem Compound 5576

Name:	Trimethadione
PubChem Compound ID:	5576
Description:	An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378)
Molecular formula:	C₆H₉NO₃
Molecular weight:	143.141 g/mol
Synonyms:	Tridilona; Trimedone; 4-27-00-03237 (Beilstein Handbook Reference); Tridone; Trimedal; 3,5,5-Trojmetylooksazolidyno-2,4-dion [Polish]; D00392; Troxidone; Edion; Trimethin. show more » Tridilona; Trimedone; 4-27-00-03237 (Beilstein Handbook Reference); Tridone; Trimedal; 3,5,5-Trojmetylooksazolidyno-2,4-dion [Polish]; D00392; Troxidone; Edion; Trimethin; EINECS 204-845-8; Trimetin; CAS-127-48-0; 2, 4-Oxazolidinedione, 3,5,5-trimethyl-; Mino-Aleviatin; Petimalin; Trimetadione [DCIT]; A 2297; Prestwick_815; 2,4-OXAZOLIDINEDIONE, 3,5,5-TRIMETHYL-; 127-48-0; Trimethadione; Neo-Absentol; Epidone; Trimethadione (JP15); SPBio_002390; Tridion; Tromedone; Minoaleuiatin; 3,3,5-Trimethyl-2,4-diketooxazolidine; Trilidona; NSC169503; Tricione; Trimethdione; Trioksal; Trimethadionum [INN-Latin]; Absentol; Prestwick1_000515; 3,3,5-Trimethyl-2, 4-diketooxazolidine; Trimethadion; Trimethadione [INN:JAN]; BRN 0121627; Epidione; Absetil; Petilep; Tridione; Convenixa; Ptimal; Tioxanona; Triozanona; Petidon; Convexina; Trimetadiona [INN-Spanish]; Tredione; Trioxanona; NCGC00016383-01; Petidion; NSC 15799; NSC15799; 3,5,5-Trimethyl-2,4-oxazolidinedione; Etydion; Trimetadione; Trimethinum; Tridione (TN); Pitmal; ZINC01530710; Minoaleviatin; Epixal; Prestwick0_000515 show less «

DrugBank

Identification

Name:	Trimethadione
Name (isomeric):	DB00347
Drug Type:	small molecule
Description:	An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378)
Synonyms:	Trimethadion; Trimethdione; Trimetadione
Brand:	Etydion, Trimethin, Trimedone, Epixal, Petidon, Edion, Tridion, Tromedone, Trioxanona, Minoaleuiatin, Tricione, Epidone, Petimalin, Tridilona, Trimedal, Convenixa, Triozanona, Ptimal, Epidione, Trilidona, Tridone, Neo-Absentol, Trimetin, Petidion, Troxidone, Mino-Aleviatin, Petilep, Pitmal, Tredione, Tridione, Minoaleviatin, Tioxanona, Absetil, Convexina, Absentol
Category:	Anticonvulsants
CAS number:	127-48-0

Pharmacology

Indication:	Used in the control of absence (petit mal) seizures that are refractory to treatment with other medications.
Pharmacology:	Paramethadione and trimethadione are anticonvulsants indicated in the control of absence (petit mal) seizures that are refractory to treatment with other medications. Dione anticonvulsants are used in the treatment of epilepsy. They act on the central nervous system (CNS) to reduce the number of seizures.
Mechanism of Action:	Dione anticonvulsants reduce T-type calcium currents in thalamic neurons, including thalamic relay neurons. It does so via the inhibition of voltage dependent T-type calcium channels. This raises the threshold for repetitive activity in the thalamus, and inhibits corticothalamic transmission. Thus, the abnormal thalamocortical rhythmicity, which is... show more » Dione anticonvulsants reduce T-type calcium currents in thalamic neurons, including thalamic relay neurons. It does so via the inhibition of voltage dependent T-type calcium channels. This raises the threshold for repetitive activity in the thalamus, and inhibits corticothalamic transmission. Thus, the abnormal thalamocortical rhythmicity, which is thought to underlie the 3-Hz spike-and-wave discharge seen on electroencephalogram(EEG) with absence seizures, is dampened. show less «
Protein binding:	90%
Toxicity:	Symptoms of overdose include clumsiness or unsteadiness, coma, dizziness (severe), drowsiness (severe), nausea (severe), and problems with vision.
Affected organisms:	Humans and other mammals

Interactions

Drug interaction:

Disulfiram	Disulfiram, a strong CYP2E1 inhibitor, may decrease the metabolism and clearance of Trimethadione, a CYP2E1 substrate. Consider alternate therapy or monitor for changes in Trimethadione therapeutic and adverse effects if Disulfiram is initiated, discontinued or dose changed.
Triprolidine	The CNS depressants, Triprolidine and Trimethadione, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.

Targets

Voltage-dependent T-type calcium channel subunit alpha-1G

Enzymes

Cytochrome P450 2E1

Cytochrome P450 3A4

Cytochrome P450 2C8

Cytochrome P450 2C9

Cytochrome P450 2C19