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QuickView for Trioxsalen (compound)

Summary
General Info

PubChem

PubChem Compound 5585

PubChem Compound 5585

Name:	Trioxsalen
PubChem Compound ID:	5585
Description:	Pigmenting photosensitizing agent obtained from several plants, mainly Psoralea corylifolia. It is administered either topically or orally in conjunction with ultraviolet light in the treatment of vitiligo.
Molecular formula:	C₁₄H₁₂O₃
Molecular weight:	228.243 g/mol
Synonyms:	4,5',8-Trimethylpsoralen; Trisoralen; NSC71047; SPBio_002818; 4,8,5'-Trimethylpsoralen; Spectrum_000169; TRIOXSALIN; Spectrum4_000883; 3902-71-4; KBioGR_001286. show more » 4,5',8-Trimethylpsoralen; Trisoralen; NSC71047; SPBio_002818; 4,8,5'-Trimethylpsoralen; Spectrum_000169; TRIOXSALIN; Spectrum4_000883; 3902-71-4; KBioGR_001286; 7H-Furo[3,2-g][1]benzopyran-7-one, 2,5,9-trimethyl-; C09314; Trioxysalen (JAN); AIDS-012118; 2,5,9-Trimethyl-7H-furo(3,2-g)(1)benzopyran-7-one; NINDS_000380; 7H-Furo[3, 2-g][1]benzopyran-7-one, 2,5,9-trimethyl-; 2,5,9-Trimethyl-7H-furo[3,2-g]chromen-7-one; 7-Oxo-2,5,9-Trimethyl-7H-furo(3,2-g)(1)benzopyron; KBio2_000649; 6-Hydroxy-beta,2,7-trimethyl-5-benzofuranacrylic acid gamma-lactone; NSC-71047; BENZOFURANACRYLIC ACID,6-HYDROXY-B,2,7-TRIMETHYL-,; KBioSS_000649; Trioxsalen [USAN]; Trioxysalen; NCI60_038883; KBio1_000380; Trimethylpsoralen; NSC 71047; EINECS 223-459-0; NCGC00016643-01; 7H-Furo(3,2-g)(1)benzopyran-7-one, 2,5,9-trimethyl-; Trioxysalene [INN-French]; antipsoriatic; AIDS012118; Trioxysalenum [INN-Latin]; 5-19-04-00472 (Beilstein Handbook Reference); 4,5', 8-Trimethylpsoralene; DivK1c_000380; KBio2_005785; KBio3_002156; Elder 8011; Trioxisaleno [INN-Spanish]; ZINC00002226; Prestwick0_000709; Prestwick1_000709; Trioxsalen; Trioxsalen (USP); SDCCGMLS-0066609.P001; 4,5',8-Trimethyl psoralen; 2', 4,8-Trimethylpsoralen; 5-Benzofuranacrylic acid, 6-hydroxy-.beta., 2,7-trimethyl-, .delta.-lactone; 2',4,8-Trimethylpsoralen; 4,5',8-Trimethylpsoralene; CAS-3902-71-4; BRN 0221723; D01034; 2,5,9-Trimethyl-7H-furo[3,2-g][1]benzopyran-7-one; Spectrum3_001378; Trisoralen (TN); KBio2_003217; Prestwick_148; Spectrum2_001083; LACTONE; SPBio_001126 show less «

DrugBank

Identification

Name:	Trioxsalen
Name (isomeric):	DB04571
Drug Type:	small molecule
Description:	Pigmenting photosensitizing agent obtained from several plants, mainly Psoralea corylifolia. It is administered either topically or orally in conjunction with ultraviolet light in the treatment of vitiligo.
Synonyms:	trioxysalen; trimethylpsoralen; trisoralen
Category:	Photosensitizing Agents
CAS number:	3902-71-4

Pharmacology

Indication:	Trioxsalen is a pigmenting photosensitizing agent used in conjunction with ultraviolet light in the treatment of vitiligo.
Pharmacology:	Trioxsalen ispharmacologically inactive but when exposed to ultraviolet radiation or sunlight it is converted to its active metabolite to produce a beneficial reaction affecting the diseased tissue.
Mechanism of Action:	After photoactivation it creates interstrand cross-links in DNA, which can cause programmed cell death.

Interactions

Food interaction:

avoid eating limes, figs, parsley, parsnips, mustard, carrots, and celery while you are being treated with trioxsalen

Drug interaction:

Phenytoin	The hydantoin decreases the effect of psoralene
Fosphenytoin	The hydantoin decreases the effect of psoralene

Targets