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QuickView for TrkC (gene)


Gene Symbol:
NTRK3 Homo sapiens Homo sapiens
Full name:
neurotrophic receptor tyrosine kinase 3
Synonyms:
GP145-TrkC, TRKC, gp145(trkC), NT-3 growth factor receptor, ETS related protein-neurotrophic receptor tyrosine kinase fusion protein, ETV6-NTRK3 fusion, neurotrophic tyrosine kinase, receptor, type 3, tyrosine kinase receptor C
Genomic Location:
Chr 15: 86220992-86600665
Description:
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sen...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Bos taurus Danio rerio Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
E12_Q6 CACTGTG_MIR128A_MIR128B RTAAACA_FREAC2_01 FXR_Q3 GATA1_01 STAT1_02 MZF1_01 GGGATGC_MIR3245P P53_DECAMER_Q2 VDR_Q3
miRNA binding sites
(Source: TargetScan):
miRNA binding sites
(Source: miRecords):
Cytogenetic Map:
chr 15
15q25.3





GO Molecular Function

neurotrophin binding | transmembrane receptor protein tyrosine kinase activity | transmembrane signaling receptor activity | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | growth factor binding | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | p53 binding | ephrin receptor activity | signaling receptor activity | purine nucleotide binding | ion binding | organic cyclic compound binding | GPI-linked ephrin receptor activity | purine ribonucleoside triphosphate binding | protein tyrosine kinase activity | protein binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | neurotrophin receptor activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | heterocyclic compound binding | small molecule binding

GO Biological Process

regulation of ERK1 and ERK2 cascade | negative regulation of phosphorylation | positive regulation of locomotion | activation of GTPase activity | positive regulation of cellular component organization | cell motility | regulation of cell morphogenesis | regulation of neurogenesis | positive regulation of axon regeneration | regulation of synapse assembly | positive regulation of apoptotic process | regulation of cell development | regulation of localization | regulation of programmed cell death | peptidyl-amino acid modification | transmembrane receptor protein tyrosine kinase activity | eye development | response to hormone | neuron migration | negative regulation of cellular process | positive regulation of developmental process | regulation of MAP kinase activity | negative regulation of astrocyte differentiation | cell differentiation | nervous system development | response to drug | negative regulation of protein phosphorylation | positive regulation of axonogenesis | neurogenesis | positive regulation of phosphate metabolic process | peptidyl-tyrosine phosphorylation | regulation of organelle organization | positive regulation of cellular component movement | generation of neurons | response to antibiotic | positive regulation of GTPase activity | cellular process | negative regulation of gliogenesis | cell fate specification | regulation of cell motility | localization | negative regulation of signaling | positive regulation of peptidyl-serine phosphorylation | positive regulation of protein kinase activity | regulation of chemotaxis | negative regulation of apoptotic process | response to corticosterone | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | regulation of neuron projection development | negative regulation of cellular metabolic process | tissue development | regulation of cell differentiation | interspecies interaction between organisms | cellular response to retinoic acid | regulation of cellular process | positive regulation of cell growth | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | response to nerve growth factor | positive regulation of cellular protein metabolic process | epithelium development | ephrin receptor signaling pathway | cellular component organization | response to stimulus | modulation by virus of host process | positive regulation of protein metabolic process | positive regulation of phosphatidylinositol 3-kinase signaling | response to stress | regulation of cell proliferation | circadian rhythm | response to alcohol | rhythmic process | positive regulation of lipase activity | regulation of neuron projection regeneration | negative regulation of metabolic process | regulation of cellular component size | positive regulation of protein serine/threonine kinase activity | regulation of axon extension | protein modification process | regulation of actin cytoskeleton reorganization | regulation of synapse structure or activity | macromolecule modification | activation of protein kinase activity | response to ethanol | neuron fate commitment | regulation of cellular response to stress | locomotion | positive regulation of phospholipase C activity | system development | positive regulation of response to wounding | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of organelle organization | negative regulation of phosphate metabolic process | positive regulation of neuron projection development | regulation of actin cytoskeleton organization | multicellular organism development | cell migration | regulation of MAPK cascade | phosphorus metabolic process | regulation of axonogenesis | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | cellular response to nerve growth factor stimulus | regulation of phosphorylation | positive regulation of neuron projection regeneration | mechanoreceptor differentiation | regulation of neuron differentiation | regulation of gene expression | positive regulation of chemotaxis | response to ketone | response to lipid | modification of morphology or physiology of other organism | positive regulation of cellular metabolic process | positive regulation of actin cytoskeleton reorganization | positive regulation of protein phosphorylation | response to axon injury | regulation of synapse organization | ephrin receptor activity | protein autophosphorylation | regulation of nitrogen compound metabolic process | regulation of cell migration | enzyme linked receptor protein signaling pathway | positive regulation of cell projection organization | positive regulation of intracellular signal transduction | response to corticosteroid | regulation of cellular component movement | positive regulation of hydrolase activity | positive regulation of cell differentiation | activation of protein kinase B activity | positive regulation of cell migration | regulation of cellular protein metabolic process | neurotrophin signaling pathway | phosphorylation | regulation of phospholipase activity | response to toxic substance | regulation of GTPase activity | protein phosphorylation | phosphate-containing compound metabolic process | sensory organ development | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | positive regulation of cytoskeleton organization | regulation of protein metabolic process | positive regulation of signal transduction | inner ear development | heart development | positive regulation of cell proliferation | regulation of protein phosphorylation | GPI-linked ephrin receptor activity | regulation of locomotion | regulation of RNA metabolic process | positive regulation of synapse assembly | response to retinoic acid | viral process | protein tyrosine kinase activity | regulation of phospholipase C activity | positive regulation of molecular function | positive regulation of axon extension involved in regeneration | positive regulation of axon extension | neuron differentiation | activation of MAPK activity | regulation of cell morphogenesis involved in differentiation | protein metabolic process | positive regulation of protein modification process | regulation of growth | response to organic substance | regulation of kinase activity | response to wounding | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | positive regulation of neurogenesis | metabolic process | positive regulation of cell development | cell fate commitment | response to mineralocorticoid | regulation of RNA biosynthetic process | negative regulation of programmed cell death | ear development | positive regulation of cell death | protein kinase activity | positive regulation of cellular component biogenesis | organic substance metabolic process | animal organ development | negative regulation of cellular protein metabolic process | positive regulation of ERK1 and ERK2 cascade | positive regulation of programmed cell death | positive regulation of kinase activity | regulation of phosphate metabolic process | neurotrophin receptor activity | positive regulation of phospholipase activity | positive regulation of MAPK cascade | camera-type eye development | regulation of axon regeneration | regulation of peptidyl-serine phosphorylation | negative regulation of protein metabolic process | regulation of glial cell differentiation | regulation of response to wounding | regulation of cell communication | regulation of gliogenesis | negative regulation of signal transduction | positive regulation of developmental growth | signaling | positive regulation of growth | response to organic cyclic compound | regulation of developmental growth | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cell size | positive regulation of MAP kinase activity | regulation of nervous system development | regulation of developmental process | kinase activity | developmental process | regulation of cell growth | negative regulation of glial cell differentiation | cellular protein modification process | modulation by virus of host morphology or physiology | cochlea development | epithelial cell differentiation | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | regulation of actin filament-based process | positive regulation of neuron differentiation | regulation of cell projection organization | cellular metabolic process | cellular response to organic substance | regulation of astrocyte differentiation | regulation of cell death | positive regulation of cell motility | response to steroid hormone | lens fiber cell differentiation | positive regulation of cell morphogenesis involved in differentiation | negative regulation of cell death | negative regulation of cell development | neuron fate specification | circulatory system development | negative regulation of cell differentiation | regulation of cellular component organization | lens development in camera-type eye | regulation of cytoskeleton organization | positive regulation of signaling | signal transduction | regulation of phosphatidylinositol 3-kinase signaling | regulation of signaling | positive regulation of gene expression | response to glucocorticoid | cellular response to growth factor stimulus | macromolecule metabolic process | negative regulation of neurogenesis | modulation by virus of host transcription | multicellular organismal process | positive regulation of positive chemotaxis | regulation of phosphorus metabolic process

GO Cellular Component

integral component of membrane | neuron projection | cell | intrinsic component of membrane | cytoplasm | receptor complex | protein-containing complex | cell projection | plasma membrane | integral component of plasma membrane | cell periphery | axon | intracellular | membrane | intrinsic component of plasma membrane