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QuickView for Troleandomycin (compound)
PubChem
| Name: | Troleandomycin |
|---|---|
| PubChem Compound ID: | 17675 |
| Description: | A macrolide antibiotic that is similar to ERYTHROMYCIN. |
| Molecular formula: | C41H67NO15 |
| Molecular weight: | 813.968 g/mol |
| Synonyms: |
Tao (VAN); Troleandomycin; Matromicina; TAO; Aovine; Triocetin; Oleandomycin, triacetyl-; Triacetyloleandomycin; EINECS 220-392-9; AI3-50166.
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DrugBank
Identification
| Name: | Troleandomycin |
|---|---|
| Name (isomeric): | DB01361 |
| Drug Type: | small molecule |
| Description: | A macrolide antibiotic that is similar to ERYTHROMYCIN. |
| Synonyms: |
Oleandomycin triacetate; Triacetyloleandomycin; Oleandomycin, triacetate (ester); Oleandocetine; Oleandomycin triacetyl ester
|
| Brand: | Tao, Matromicina, Cyclamycin, Treolmicina, Tribiocillina, Evramicina |
| Category: | Anti-Bacterial Agents, Antibacterial Agents, Macrolides |
| CAS number: | 2751-09-9 |
Pharmacology
| Indication: | For the treatment of Pneumococcal pneumonia due to susceptible strains and group A beta-hemolytic streptococcal infections of the upper respiratory tract. |
|---|---|
| Pharmacology: | Troleandomycin is a macrolide antibiotic that is similar to erythromycin. It is active in vitro against the following gram-positive organisms: Streptococcus pyogenes and Diplococcus pneumoniae. |
| Mechanism of Action: |
Troleandomycin acts by penetrating the bacterial cell membrane and reversibly binding to the 50 S subunit of bacterial ribosomes or near the "P" or donor site so that binding of tRNA (transfer RNA) to the donor site is blocked. Translocation of peptides from the "A" or acceptor site to the "P" or donor site is prevented, and subsequent protein synt...
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| Toxicity: | Symptoms of overdose include diarrhea, nausea, stomach cramps, and vomiting. |
| Affected organisms: | Enteric bacteria and other eubacteria |
Interactions
| Drug interaction: |
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Targets
Enzymes
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