Correlation Engine 2.0
Clear Search sequence regions
Bookmark Forward

QuickView for Trovafloxacin (compound)


PubChem
Name: trovafloxacin
PubChem Compound ID: 11611373
Molecular formula: C20H15F3N4O3
Molecular weight: 415.356 g/mol
DrugBank
Identification
Name: trovafloxacin
Name (isomeric): DB00685
Drug Type: small molecule
Synonyms:
TVFX; Trovafloxacin mesylate
Brand: Trovan
Brand name mixture: Trovan/Zithromax Compliance Pak(Trovafloxacin + Azithromycin)
Category: Anti-Infective Agents, Fluoroquinolones, Quinolones, Anti-Infectives
CAS number: 147059-72-1
Pharmacology
Indication: For treatment of infections caused by susceptible strains of the designated microorganisms in uncomplicated urethral gonorrhea in males and endocervical and rectal gonorrhea in females caused by <i>Neisseria gonorrhoeae</i> as well as non gonoccocal urethritis and cervicitis due to <i>Chlamydia trachomatis</i>.
Pharmacology:
Trovafloxacin is a broad spectrum antibiotic that inhibits DNA supercoiling in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It is not used widely due to the risk of hepatotoxicity. It tends to have better gram-positive bacterial coverage and less gram-negative coverage than the previous fluoroquinolones. Mechanism o...
show more »
Mechanism of Action:
Trovafloxacin is a fluoronaphthyridone related to the fluoroquinolones with in vitro activity against a wide range of gram-negative and gram-positive aerobic and anaerobic microorganisms. The bactericidal action of trovafloxacin results from inhibition of DNA gyrase and topoisomerase IV. DNA gyrase is an essential enzyme that is involved in the rep...
show more »
Absorption: Well-absorbed from the gastrointestinal tract after oral administration and does not depend on concomitant food intake. The absolute bioavailability is approximately 88%.
Protein binding: The mean plasma protein bound fraction is approximately 76%, and is concentration-independent.
Biotransformation: Metabolism Trovafloxacin is metabolized by conjugation (the role of cytochrome P450 oxidative metabolism of trovafloxacin is minimal). The major metabolites include the ester glucuronide, which appears in the urine (13% of the administered dose); and the N -acetyl metabolite, which appears in the feces and serum (9% and 2.5% of the administered dose, respectively). Other minor metabolites include diacid, hydroxycarboxylic acid, and sulfamate, which have been identified in both the feces and the urine in small amounts (< 4% of the administered dose).
Route of elimination: Approximately 50% of an oral dose is excreted unchanged (43% in the feces and 6% in the urine).
Half Life: Following oral administration, half-life ranged from 9.1 hours to 12.2 hours over the dosage range of 100 to 200 mg tablets. Following intravenous infusion, half-life ranged from 9.4 to 12.7 hours over a dosage range of 100 to 300 mg.
Toxicity: Symptoms of overdose include convulsions, decreased activity, diarrhea, sleepiness, tremors, and/or vomiting.
Affected organisms: Enteric bacteria and other eubacteria
Interactions
Drug interaction:
Magnesium oxideMagnesium may decrease the absorption of orally administered Trovafloxacin. Administer Trovafloxacin 2 hours before or 6 hours after a dose of the magnesium containing agent to minimize the interaction.
MorphineMorphine may reduce serum levels of Trovafloxacin decreasing the efficacy of the antibiotic. IV doses of morphine should be administered at least 2 hours after a dose of Trovafloxacin given in a fasting state or 4 hours after if given in a fed state.
Calcium ChlorideCalcium may decrease the absorption of orally administered Trovafloxacin. Administer Trovafloxacin 2 hours before or 6 hours after a dose of the calcium containing agent to minimize the interaction.
IronIron may decrease the absorption of orally administered Trovafloxacin. Administer Trovafloxacin 2 hours before or 6 hours after a dose of the iron containing agent to minimize the interaction.
SevelamerSevelamer may decrease the absorption of orally administered Trovafloxacin. The Sevelamer formulation contains iron that may intefere with Trovafloxacin absorption. Administer Trovafloxacin 2 hours before or 6 hours after the Sevelamer dose to minimize the interaction.
show more »

Targets