QuickView for Tufm (gene)
- Gene Symbol:
- TUFM
Homo sapiens - Full name:
- Tu translation elongation factor, mitochondrial
- Synonyms:
- COXPD4, EF-TuMT, EFTU, P43, elongation factor Tu, mitochondrial, EF-Tu
- Genomic Location:
- Chr 16: 28761613-28765144
- Description:
-
This gene encodes a protein which participates in protein translation in mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency resulting in lactic acidosis and fatal encephalopathy. A pseudogene has been identified on chromosome 17.
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Bos taurus , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
16p11.2
GO Molecular Function
guanyl ribonucleotide binding | ribonucleoside binding | translation elongation factor activity | nucleic acid binding | ribonucleotide binding | nucleotide binding | hydrolase activity | carbohydrate derivative binding | pyrophosphatase activity | catalytic activity | anion binding | nucleoside-triphosphatase activity | purine nucleotide binding | translation factor activity, RNA binding | ion binding | organic cyclic compound binding | GTPase activity | purine nucleoside binding | purine ribonucleoside triphosphate binding | protein binding | GTP binding | hydrolase activity, acting on acid anhydrides | nucleoside binding | purine ribonucleotide binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | guanyl nucleotide binding | small molecule binding | RNA binding
GO Biological Process
translational elongation | response to drug | response to antibiotic | translation elongation factor activity | cellular process | mitochondrial translational elongation | response to stimulus | peptide biosynthetic process | mitochondrial translation | cellular nitrogen compound biosynthetic process | response to alcohol | cellular nitrogen compound metabolic process | cellular biosynthetic process | response to ethanol | nitrogen compound metabolic process | cellular amide metabolic process | translation | translation factor activity, RNA binding | biosynthetic process | response to toxic substance | peptide metabolic process | protein metabolic process | response to organic substance | metabolic process | mitochondrial gene expression | organic substance metabolic process | gene expression | amide biosynthetic process | cellular protein metabolic process | cellular macromolecule biosynthetic process | cellular metabolic process | macromolecule metabolic process
GO Cellular Component
mitochondrial matrix | intracellular membrane-bounded organelle | cell | mitochondrial nucleoid | cytoplasm | nucleoid | intracellular organelle | vesicle | extracellular exosome | mitochondrion | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | membrane-enclosed lumen | intracellular | myelin sheath | membrane
