QuickView for Tumor%20Suppressor%20p53 (gene)
- Gene Symbol:
- Trp53
Mus musculus - Full name:
- transformation related protein 53
- Synonyms:
- Tp53, bbl, bfy, bhy, p44, p53, cellular tumor antigen p53, mutant p53, p53 cellular tumor antigen, tumor suppressor p53, tumor supressor p53
- Genomic Location:
- Chr 11: 69393483-69405373
- Description:
-
This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to t...
- Orthologs:
- Homo sapiens , Rattus norvegicus , Macaca mulatta , Bos taurus , Danio rerio , Gallus gallus , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
AACTTT_UNKNOWN , SOX5_01 , NFKAPPAB65_01 , CREL_01 , NFKAPPAB_01 , MZF1_02 , MYCMAX_02 , ACTAYRNNNCCCR_UNKNOWN , HNF4_01 , AHR_01
GO Molecular Function
sequence-specific DNA binding | protein self-association | kinase binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | core promoter binding | histone deacetylase regulator activity | protein phosphatase 2A binding | enhancer binding | cation binding | protein kinase binding | proximal promoter sequence-specific DNA binding | receptor tyrosine kinase binding | enzyme binding | nucleic acid binding | ribonucleotide binding | disordered domain specific binding | mRNA binding | nucleotide binding | signaling receptor binding | carbohydrate derivative binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | molecular function regulator | chromatin binding | chaperone binding | protein domain specific binding | ATP binding | protein N-terminus binding | ubiquitin-like protein ligase binding | TFIID-class transcription factor binding | anion binding | adenyl nucleotide binding | enhancer sequence-specific DNA binding | RNA polymerase II regulatory region DNA binding | p53 binding | DNA binding | MDM2/MDM4 family protein binding | sequence-specific double-stranded DNA binding | purine nucleotide binding | promoter-specific chromatin binding | identical protein binding | protein heterodimerization activity | ion binding | organic cyclic compound binding | protein tyrosine kinase binding | copper ion binding | transcription regulatory region sequence-specific DNA binding | purine ribonucleoside triphosphate binding | protein binding | histone acetyltransferase binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | protein phosphatase binding | transcription factor binding | ubiquitin protein ligase binding | RNA polymerase II transcription factor binding | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | RNA polymerase II distal enhancer sequence-specific DNA binding | transition metal ion binding | core promoter sequence-specific DNA binding | purine ribonucleotide binding | enzyme regulator activity | adenyl ribonucleotide binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding involved in preinitiation complex assembly | drug binding | transcription factor activity, core RNA polymerase binding | protease binding | phosphatase binding | mRNA 3'-UTR binding | transcription cofactor binding | histone deacetylase binding | metal ion binding | basal RNA polymerase II transcription machinery binding | heterocyclic compound binding | protein C-terminus binding | small molecule binding | RNA binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | response to extracellular stimulus | positive regulation of transcription from RNA polymerase II promoter in response to hypoxia | regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter | brain development | protein homooligomerization | double-strand break repair | DNA-templated transcription, initiation | response to radiation | regulation of hydrogen peroxide-induced cell death | regulation of cell cycle process | cellular response to glucose starvation | cellular response to decreased oxygen levels | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | response to nutrient levels | positive regulation of cell aging | response to endoplasmic reticulum stress | release of cytochrome c from mitochondria | DNA strand renaturation | response to cytokine | regulation of cellular response to oxidative stress | positive regulation of cellular component organization | regulation of response to oxidative stress | regulation of neurogenesis | intracellular signal transduction | positive regulation of apoptotic process | regulation of cell development | protein stabilization | regulation of localization | regulation of cell cycle G1/S phase transition | regulation of carbohydrate metabolic process | regulation of programmed cell death | regulation of mitochondrial membrane permeability involved in apoptotic process | positive regulation of peptidyl-tyrosine phosphorylation | T cell lineage commitment | regulation of cell aging | response to X-ray | necroptotic process | mitochondrial DNA metabolic process | establishment of localization | regulation of autophagy | regulation of immune system process | negative regulation of neuroblast proliferation | regulation of transforming growth factor beta receptor signaling pathway | neuron death | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | positive regulation of developmental process | negative regulation of RNA biosynthetic process | regulation of cardiac muscle cell apoptotic process | cell differentiation | positive regulation of intrinsic apoptotic signaling pathway | defense response | nervous system development | intrinsic apoptotic signaling pathway in response to DNA damage | cellular response to extracellular stimulus | negative regulation of mitochondrion organization | response to drug | multicellular organism growth | cellular chemical homeostasis | histone deacetylase regulator activity | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | regulation of G1/S transition of mitotic cell cycle | neurogenesis | positive regulation of phosphate metabolic process | regulation of protein oligomerization | regulation of DNA replication | regulation of organelle organization | positive regulation of cellular component movement | negative regulation of glucose catabolic process to lactate via pyruvate | generation of neurons | membrane organization | B cell differentiation | response to antibiotic | intracellular transport | regulation of neuroblast proliferation | negative regulation of DNA metabolic process | negative regulation of proteolysis | pattern specification process | regulation of neuron death | positive regulation of cellular biosynthetic process | regulation of transcription initiation from RNA polymerase II promoter | cellular process | negative regulation of DNA biosynthetic process | lymphocyte differentiation | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress | regulation of cell motility | localization | cellular homeostasis | regulation of glycolytic process | chromatin organization | mitotic DNA integrity checkpoint | protein transport | heart morphogenesis | negative regulation of macroautophagy | negative regulation of signaling | developmental growth | negative regulation of G1/S transition of mitotic cell cycle | positive regulation of reactive oxygen species metabolic process | programmed necrotic cell death | immune system development | negative regulation of nucleic acid-templated transcription | macromolecule localization | regulation of histone modification | negative regulation of apoptotic process | response to hypoxia | positive regulation of release of cytochrome c from mitochondria | cellular response to starvation | regulation of proteolysis | positive regulation of T cell apoptotic process | regulation of cell cycle | response to growth factor | positive regulation of nitrogen compound metabolic process | positive regulation of muscle cell apoptotic process | establishment of localization in cell | negative regulation of cellular metabolic process | tissue development | regulation of cell differentiation | interspecies interaction between organisms | DNA geometric change | intrinsic apoptotic signaling pathway | regulation of lymphocyte apoptotic process | regulation of cellular process | leukocyte activation | regulation of apoptotic process | regulation of metabolic process | interferon-gamma-mediated signaling pathway | catabolic process | regulation of protein complex assembly | protein import into nucleus | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | epithelium development | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | signal transduction involved in mitotic DNA damage checkpoint | cellular component organization | negative regulation of nucleotide metabolic process | response to transforming growth factor beta | T cell activation | cellular response to interferon-gamma | response to UV | head development | negative regulation of DNA replication | stress-induced premature senescence | response to stimulus | regulation of mitotic cell cycle phase transition | regulation of peptidyl-tyrosine phosphorylation | metencephalon development | positive regulation of immune system process | positive regulation of protein metabolic process | mononuclear cell proliferation | response to salt stress | cellular response to light stimulus | cellular response to hypoxia | response to stress | intracellular protein transport | leukocyte activation involved in immune response | cellular nitrogen compound biosynthetic process | regulation of response to drug | regulation of cell proliferation | response to peptide | protein localization to nucleus | regulation of cell cycle phase transition | circadian rhythm | response to starvation | response to actinomycin D | positive regulation of protein deacetylation | positive regulation of thymocyte apoptotic process | programmed cell death | protein-DNA complex assembly | cellular localization | rhythmic process | cellular nitrogen compound metabolic process | response to ischemia | regulation of macroautophagy | apoptotic mitochondrial changes | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | hemopoiesis | cellular component assembly | mRNA metabolic process | cellular biosynthetic process | embryo development | mitochondrion organization | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | cellular response to UV-C | positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus | negative regulation of autophagy of mitochondrion | molecular function regulator | positive regulation of membrane permeability | positive regulation of mitochondrion organization | DNA repair | anterior/posterior pattern specification | regulation of nucleic acid-templated transcription | negative regulation of cellular response to transforming growth factor beta stimulus | leukocyte differentiation | regulation of cellular response to stress | response to nitrogen compound | apoptotic process | cellular response to actinomycin D | response to light stimulus | negative regulation of mitophagy | system development | cellular response to nutrient levels | response to oxygen levels | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of mitotic cell cycle phase transition | positive regulation of organelle organization | DNA damage response, signal transduction by p53 class mediator | negative regulation of growth | regulation of protein stability | negative regulation of phosphate metabolic process | cellular response to antibiotic | mitotic DNA damage checkpoint | multicellular organism development | negative regulation of catalytic activity | negative regulation of ATP metabolic process | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly | protein import into nucleus, translocation | cellular response to DNA damage stimulus | protein complex oligomerization | regulation of catalytic activity | cerebellum development | cellular response to oxidative stress | ER-nucleus signaling pathway | regulation of phosphorylation | regulation of intrinsic apoptotic signaling pathway | ncRNA transcription | positive regulation of chromosome organization | DNA damage response, signal transduction resulting in transcription | positive regulation of cell cycle | signal transduction in response to DNA damage | regulation of gene expression | T cell proliferation involved in immune response | oligodendrocyte apoptotic process | regulation of mitochondrial membrane permeability | rhythmic behavior | organic substance transport | cellular response to stress | cellular response to peptide | cell cycle | regulation of stem cell proliferation | regulation of signal transduction by p53 class mediator | regulation of cell cycle arrest | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of telomerase activity | cellular ion homeostasis | cellular response to radiation | animal organ morphogenesis | regulation of pri-miRNA transcription by RNA polymerase II | negative regulation of smooth muscle cell proliferation | mitochondrial transport | cellular response to oxygen levels | glial cell apoptotic process | regulation of nitrogen compound metabolic process | regulation of cell migration | enzyme linked receptor protein signaling pathway | neuron apoptotic process | peptide transport | cytokine-mediated signaling pathway | negative regulation of cellular response to growth factor stimulus | positive regulation of intracellular signal transduction | positive regulation of protein complex assembly | regulation of cellular component movement | regulation of transcription by RNA polymerase II | protein homotetramerization | cellular response to gamma radiation | response to oxidative stress | rRNA transcription | protein localization to organelle | import into nucleus | positive regulation of cell migration | cellular response to cytokine stimulus | B cell activation | cell proliferation | leukocyte proliferation | biosynthetic process | response to osmotic stress | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | positive regulation of transcription from RNA polymerase II promoter in response to stress | hindbrain development | oxidative stress-induced premature senescence | T cell activation involved in immune response | positive regulation of pri-miRNA transcription by RNA polymerase II | regulation of RNA polymerase II transcriptional preinitiation complex assembly | cardiac septum morphogenesis | cellular protein-containing complex assembly | positive regulation of neuron death | protein tetramerization | positive regulation of leukocyte apoptotic process | rRNA metabolic process | regulation of apoptotic signaling pathway | DNA-templated transcriptional preinitiation complex assembly | signal transduction involved in cell cycle checkpoint | response to gamma radiation | RNA polymerase II transcriptional preinitiation complex assembly | cation homeostasis | regulation of leukocyte migration | cellular response to UV | autophagy | negative regulation of autophagy | protein import | regulation of mitochondrion organization | regulation of cellular response to drug | mitotic G1 DNA damage checkpoint | regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter | mitochondrial membrane organization | regulation of muscle cell apoptotic process | chordate embryonic development | positive regulation of histone deacetylation | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | mitochondrial genome maintenance | transmembrane receptor protein serine/threonine kinase signaling pathway | regulation of protein deacetylation | regulation of neuron apoptotic process | regulation of intracellular pH | regulation of T cell apoptotic process | cell activation involved in immune response | regulation of protein metabolic process | positive regulation of signal transduction | heart development | negative regulation of stem cell proliferation | homeostatic process | mRNA transcription | regulation of protein phosphorylation | intrinsic apoptotic signaling pathway in response to hypoxia | regulation of locomotion | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | viral process | negative regulation of cell growth | regulation of cellular response to growth factor stimulus | apoptotic signaling pathway | cell aging | embryonic morphogenesis | ER overload response | mitochondrial DNA repair | regulation of mitotic cell cycle | regulation of autophagy of mitochondrion | lymphocyte activation | cellular response to transforming growth factor beta stimulus | positive regulation of cell cycle arrest | positive regulation of execution phase of apoptosis | T cell differentiation | protein-containing complex assembly | negative regulation of carbohydrate metabolic process | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | regulation of fibroblast proliferation | DNA-binding transcription factor activity | regionalization | negative regulation of transforming growth factor beta receptor signaling pathway | positive regulation of protein modification process | regulation of growth | response to organic substance | T cell differentiation in thymus | G1 DNA damage checkpoint | cell cycle arrest | regulation of pH | DNA metabolic process | replicative senescence | regulation of response to reactive oxygen species | regulation of intracellular signal transduction | chromatin assembly or disassembly | positive regulation of neuron apoptotic process | establishment of protein localization to organelle | anatomical structure development | mitotic cell cycle | cell surface receptor signaling pathway | entrainment of circadian clock | regulation of glucose metabolic process | regulation of neural precursor cell proliferation | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | metabolic process | cell fate commitment | nucleotide-excision repair | regulation of DNA-templated transcription in response to stress | positive regulation of DNA-templated transcription, initiation | regulation of thymocyte apoptotic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | embryonic organ development | negative regulation of mitotic cell cycle | cellular protein localization | regulation of tissue remodeling | amide transport | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | chemical homeostasis | behavior | positive regulation of cell death | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | immune response | nucleobase-containing compound metabolic process | cellular response to reactive oxygen species | positive regulation of mitochondrial membrane permeability | positive regulation of cellular component biogenesis | organic substance metabolic process | nuclear transport | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | positive regulation of histone modification | response to reactive oxygen species | negative regulation of cellular protein metabolic process | T cell proliferation | gene expression | positive regulation of leukocyte migration | positive regulation of programmed cell death | signal transduction involved in mitotic cell cycle checkpoint | ion homeostasis | cellular response to ionizing radiation | regulation of ATP metabolic process | regulation of phosphate metabolic process | DNA packaging | regulation of chromosome organization | intrinsic apoptotic signaling pathway by p53 class mediator | establishment of protein localization | transcription initiation from RNA polymerase II promoter | transcription, DNA-templated | response to interferon-gamma | regulation of cellular pH | cell activation | positive regulation of lymphocyte apoptotic process | chromatin assembly | transforming growth factor beta receptor signaling pathway | negative regulation of fermentation | anatomical structure formation involved in morphogenesis | positive regulation of cardiac muscle cell apoptotic process | negative regulation of cell cycle | negative regulation of protein metabolic process | B cell lineage commitment | lymphocyte proliferation | multicellular organism aging | regulation of cell communication | negative regulation of cell cycle G1/S phase transition | regulation of membrane permeability | negative regulation of molecular function | cellular senescence | negative regulation of signal transduction | signaling | somite development | mitotic cell cycle arrest | regulation of transcription, DNA-templated | response to UV-C | cellular monovalent inorganic cation homeostasis | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator | determination of adult lifespan | protein localization | negative regulation of fibroblast proliferation | positive regulation of phosphorylation | enzyme regulator activity | regulation of transcription from RNA polymerase II promoter in response to stress | anatomical structure morphogenesis | cellular macromolecule localization | cellular macromolecule biosynthetic process | regulation of DNA-templated transcription, initiation | signal transduction involved in DNA damage checkpoint | response to biotic stimulus | nucleocytoplasmic transport | regulation of circadian rhythm | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding involved in preinitiation complex assembly | regulation of nervous system development | regulation of developmental process | transcription factor activity, core RNA polymerase binding | regulation of transcription from RNA polymerase II promoter in response to hypoxia | regulation of intrinsic apoptotic signaling pathway by p53 class mediator | segmentation | developmental process | organelle organization | regulation of DNA biosynthetic process | positive regulation of cell cycle process | regulation of cell growth | cardiac septum development | mitotic G1/S transition checkpoint | negative regulation of transcription by RNA polymerase II | positive regulation of transcription, DNA-templated | regulation of reactive oxygen species metabolic process | positive regulation of protein oligomerization | necrotic cell death | negative regulation of cell proliferation | negative regulation of neural precursor cell proliferation | innate immune response | ncRNA metabolic process | circadian behavior | positive regulation of nucleic acid-templated transcription | entrainment of circadian clock by photoperiod | DNA conformation change | response to organonitrogen compound | positive regulation of transcription by RNA polymerase II | photoperiodism | cardiac chamber development | heterocycle metabolic process | regulation of fibroblast apoptotic process | regulation of histone deacetylation | somitogenesis | signal transduction involved in mitotic G1 DNA damage checkpoint | central nervous system development | regulation of generation of precursor metabolites and energy | in utero embryonic development | positive regulation of metabolic process | chromosome organization | regulation of execution phase of apoptosis | gastrulation | immune system process | mitotic cell cycle checkpoint | cellular metabolic process | hematopoietic or lymphoid organ development | negative regulation of cell cycle process | cellular response to organic substance | regulation of cell death | regulation of smooth muscle cell proliferation | positive regulation of cell motility | DNA damage checkpoint | cell cycle checkpoint | signal transduction by p53 class mediator | negative regulation of cell death | negative regulation of cell development | circulatory system development | aging | negative regulation of telomerase activity | negative regulation of cell differentiation | regulation of cellular component organization | response to ionizing radiation | positive regulation of transcription initiation from RNA polymerase II promoter | positive regulation of apoptotic signaling pathway | negative regulation of reactive oxygen species metabolic process | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | cellular response to growth factor stimulus | macromolecule metabolic process | negative regulation of neurogenesis | regulation of cellular senescence | multicellular organismal process | regulation of chromatin organization | regulation of phosphorus metabolic process
GO Cellular Component
nuclear transcription factor complex | mitochondrial matrix | site of DNA damage | chromosome | intracellular membrane-bounded organelle | catalytic complex | RNA polymerase II transcription factor complex | cell | nuclear lumen | transcription factor complex | replication fork | nucleolus | cytoplasm | intracellular organelle | endoplasmic reticulum | nuclear body | protein-containing complex | PML body | endomembrane system | nucleoplasm | chromatin | nuclear chromosome | transferase complex | mitochondrion | site of double-strand break | membrane-bounded organelle | nucleus | organelle | nuclear DNA-directed RNA polymerase complex | transcription factor TFIID complex | RNA polymerase complex | membrane-enclosed lumen | nuclear matrix | nuclear chromatin | cytosol | intracellular | RNA polymerase II, holoenzyme | nuclear periphery
