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QuickView for Tuple1 (gene)

Gene Symbol:
HIRA Homo sapiens Homo sapiens
Full name:
histone cell cycle regulator
DGCR1, TUP1, TUPLE1, protein HIRA, DiGeorge critical region gene 1, HIR histone cell cycle regulation defective homolog A, TUP1-like enhancer of split protein 1
Genomic Location:
Chr 22: 17698224-17799219
This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci like...
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 22

Transcripts Names
Protein Names

GO Molecular Function

nucleosome binding | nucleic acid binding | protein-containing complex binding | chromatin binding | DNA binding | transcription corepressor activity | organic cyclic compound binding | protein binding | DNA-binding transcription factor activity | transcription coregulator activity | heterocyclic compound binding

GO Biological Process

RNA metabolic process | nucleosome organization | negative regulation of cellular process | negative regulation of RNA biosynthetic process | cell differentiation | regulation of organelle organization | cellular process | regulation of gene expression, epigenetic | chromatin organization | negative regulation of nucleic acid-templated transcription | negative regulation of cellular metabolic process | muscle structure development | muscle cell differentiation | regulation of cellular process | gene silencing | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | chromosome segregation | cellular nitrogen compound biosynthetic process | protein-DNA complex assembly | regulation of gene silencing | cellular nitrogen compound metabolic process | negative regulation of metabolic process | cellular component assembly | cellular biosynthetic process | embryo development | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | multicellular organism development | sister chromatid segregation | regulation of gene expression | cell cycle | negative regulation of gene expression, epigenetic | DNA replication-independent nucleosome assembly | regulation of nitrogen compound metabolic process | transcription corepressor activity | regulation of transcription by RNA polymerase II | biosynthetic process | aromatic compound biosynthetic process | cellular protein-containing complex assembly | nuclear chromosome segregation | regulation of cellular metabolic process | regulation of RNA metabolic process | embryonic morphogenesis | protein-containing complex assembly | DNA-binding transcription factor activity | chromatin assembly or disassembly | anatomical structure development | mitotic cell cycle | nuclear division | metabolic process | regulation of chromatin silencing | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | gene expression | DNA packaging | regulation of chromosome organization | mitotic nuclear division | transcription, DNA-templated | chromatin assembly | regulation of transcription, DNA-templated | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | developmental process | organelle organization | DNA replication-independent nucleosome organization | DNA conformation change | transcription coregulator activity | heterocycle metabolic process | chromatin silencing at centromere | nucleosome assembly | chromosome organization | ossification | chromatin silencing | osteoblast differentiation | gastrulation | cellular metabolic process | mitotic sister chromatid segregation | regulation of cellular component organization | macromolecule metabolic process | multicellular organismal process | regulation of chromatin organization

GO Cellular Component

chromosome | intracellular membrane-bounded organelle | cell | nuclear lumen | intracellular organelle | nuclear body | HIR complex | protein-containing complex | PML body | nucleoplasm | chromatin | nuclear chromosome | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | extracellular space | membrane-enclosed lumen | nuclear chromatin | intracellular