QuickView for Tuple1 (gene)

Gene Symbol:

HIRA Homo sapiens

Full name:

histone cell cycle regulator

Synonyms:

DGCR1, TUP1, TUPLE1, protein HIRA, DiGeorge critical region gene 1, HIR histone cell cycle regulation defective homolog A, TUP1-like enhancer of split protein 1

Genomic Location:

Chr 22: 17698224-17799219

Description:

This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci like...

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This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATA1_01 ,  ARNT_01 ,  CACGTG_MYC_Q2 ,  E2F4DP1_01 ,  GCANCTGNY_MYOD_Q6 ,  MAX_01 ,  ARNT_02 ,  E2F_Q6 ,  LFA1_Q6 ,  E2F1_Q6_01 ,  CAGGTG_E12_Q6 ,  ZID_01 ,  E2F_Q4 ,  MYCMAX_01 ,  E2F1DP2_01 ,  HIF1_Q5 ,  ACTGAAA_MIR30A3P_MIR30E3P ,  TGCCAAR_NF1_Q6 ,  SPZ1_01 ,  AP2_Q3 ,  E2F1DP1_01 ,  RNGTGGGC_UNKNOWN ,  SCGGAAGY_ELK1_02 ,  GATA4_Q3 ,  E2F_02 ,  CTGCAGY_UNKNOWN ,  PAX_Q6 ,  AGGGCAG_MIR18A ,  E2F1_Q3 ,  CCGNMNNTNACG_UNKNOWN ,  E2F4DP2_01 ,  CTTTGT_LEF1_Q2 ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  HNF4_01_B ,  E2F1_Q6 ,  SGCGSSAAA_E2F1DP2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-30-3p ,  Predicted Gene Targets for miR-325 ,  Predicted Gene Targets for miR-384

Cytogenetic Map:

22q11.21

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