QuickView for UACA;jsessionid=BBEB1455651D8619390323AE4B779F32 (gene)

Gene Symbol:

UACA Homo sapiens

Full name:

uveal autoantigen with coiled-coil domains and ankyrin repeats

Synonyms:

NUCLING, uveal autoantigen with coiled-coil domains and ankyrin repeats, nuclear membrane binding protein

Genomic Location:

Chr 15: 68733947-68842904

Description:

This gene encodes a protein that contains ankyrin repeats and coiled coil domains and likely plays a role in apoptosis. Studies in rodents have implicated the encoded protein in the stimulation of apoptosis and the regulation of mammary gland involution, in which the mammary gland returns to its pre-pregnant state. This protein has also been propos...

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This gene encodes a protein that contains ankyrin repeats and coiled coil domains and likely plays a role in apoptosis. Studies in rodents have implicated the encoded protein in the stimulation of apoptosis and the regulation of mammary gland involution, in which the mammary gland returns to its pre-pregnant state. This protein has also been proposed to negatively regulate apoptosis based on experiments in human cell lines in which the protein was shown to interact with PRKC apoptosis WT1 regulator protein, also known as PAR-4, and inhibit translocation of the PAR-4 receptor. Autoantibodies to this protein have been identified in human patients with panuveitis and Graves' disease. Differential expression of this gene has been observed in various human cancers.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Bos taurus ,  Canis lupus familiaris ,  Gallus gallus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  NFKAPPAB_01 ,  NFKAPPAB65_01 ,  CAGGTG_E12_Q6 ,  MYOGENIN_Q6 ,  NFKB_Q6_01 ,  NFKB_Q6 ,  NFKB_C

Cytogenetic Map:

15q23

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