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QuickView for UBA52;jsessionid=911526D99B9DCA5D36BD41EF59FD61D4 (gene)


Gene Symbol:
UBA52 Homo sapiens Homo sapiens
Full name:
ubiquitin A-52 residue ribosomal protein fusion product 1
Synonyms:
CEP52, HUBCEP52, L40, RPL40, ubiquitin-60S ribosomal protein L40, ubiquitin carboxyl extension protein 52, ubiquitin-52 amino acid fusion protein, ubiquitin-CEP52
Genomic Location:
Chr 19: 18543614-18549270
Description:
Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either po...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Gallus gallus Canis lupus familiaris Bos taurus Danio rerio Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 19
19p13.11





GO Molecular Function

structural molecule activity | enzyme binding | ubiquitin-like protein ligase binding | protein tag | structural constituent of ribosome | protein binding | ubiquitin protein ligase binding

GO Biological Process

positive regulation of immune response | protein modification by small protein removal | RNA metabolic process | interstrand cross-link repair | nucleotide-binding oligomerization domain containing signaling pathway | error-free translesion synthesis | cellular response to decreased oxygen levels | positive regulation of macromolecule biosynthetic process | peroxisome organization | detection of stimulus | nucleotide-excision repair, DNA damage recognition | response to cytokine | response to interleukin-1 | immune response-regulating signaling pathway | intracellular signal transduction | positive regulation of apoptotic process | proteolysis | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | positive regulation of DNA-binding transcription factor activity | regulation of programmed cell death | translesion synthesis | establishment of localization | regulation of immune system process | protein targeting to ER | regulation of transforming growth factor beta receptor signaling pathway | negative regulation of cellular process | regulation of MAP kinase activity | negative regulation of RNA biosynthetic process | SRP-dependent cotranslational protein targeting to membrane | positive regulation of phosphate metabolic process | membrane organization | intracellular transport | innate immune response-activating signal transduction | positive regulation of cellular biosynthetic process | cellular process | toll-like receptor signaling pathway | organic substance catabolic process | localization | proteolysis involved in cellular protein catabolic process | protein transport | negative regulation of signaling | protein targeting to peroxisome | protein localization to endoplasmic reticulum | negative regulation of nucleic acid-templated transcription | global genome nucleotide-excision repair | positive regulation of protein kinase activity | macromolecule localization | negative regulation of apoptotic process | postreplication repair | response to hypoxia | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | establishment of localization in cell | negative regulation of cellular metabolic process | interspecies interaction between organisms | regulation of mRNA stability | regulation of immune response | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | catabolic process | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | cellular aromatic compound metabolic process | cotranslational protein targeting to membrane | cellular component organization | protein deubiquitination | MAPK cascade | viral life cycle | mRNA catabolic process | response to transforming growth factor beta | response to stimulus | peptide biosynthetic process | JNK cascade | positive regulation of innate immune response | positive regulation of immune system process | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | endosomal transport | cellular response to hypoxia | response to stress | intracellular protein transport | cellular nitrogen compound biosynthetic process | posttranscriptional regulation of gene expression | anaphase-promoting complex-dependent catabolic process | protein-DNA complex assembly | activation of innate immune response | cellular protein catabolic process | cellular localization | cellular nitrogen compound metabolic process | proteasomal protein catabolic process | immune response-activating signal transduction | nucleic acid phosphodiester bond hydrolysis | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | cellular component assembly | protein modification process | mRNA metabolic process | nuclear-transcribed mRNA catabolic process | cellular biosynthetic process | macromolecule modification | nucleobase-containing compound catabolic process | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | cell-cell signaling | activation of protein kinase activity | cell surface receptor signaling pathway involved in cell-cell signaling | translational initiation | stress-activated protein kinase signaling cascade | DNA repair | intracellular transport of virus | regulation of nucleic acid-templated transcription | negative regulation of cellular response to transforming growth factor beta stimulus | response to oxygen levels | nitrogen compound metabolic process | regulation of signal transduction | pattern recognition receptor signaling pathway | Wnt signaling pathway | regulation of MAPK cascade | phosphorus metabolic process | cellular response to DNA damage stimulus | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | nucleotide-excision repair, DNA incision, 5'-to lesion | regulation of gene expression | DNA biosynthetic process | protein localization to membrane | organic substance transport | cellular response to stress | protein catabolic process | RNA catabolic process | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | error-prone translesion synthesis | cellular response to oxygen levels | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | enzyme linked receptor protein signaling pathway | interleukin-1-mediated signaling pathway | peptide transport | cytokine-mediated signaling pathway | negative regulation of cellular response to growth factor stimulus | positive regulation of intracellular signal transduction | regulation of RNA stability | cellular amide metabolic process | vesicle-mediated transport | regulation of transcription by RNA polymerase II | protein localization to organelle | translation | cellular response to cytokine stimulus | biosynthetic process | stress-activated MAPK cascade | regulation of cellular protein metabolic process | TRIF-dependent toll-like receptor signaling pathway | aromatic compound biosynthetic process | phosphorylation | cellular protein-containing complex assembly | establishment of protein localization to peroxisome | protein phosphorylation | phosphate-containing compound metabolic process | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | transmembrane receptor protein serine/threonine kinase signaling pathway | regulation of protein metabolic process | positive regulation of signal transduction | aromatic compound catabolic process | regulation of protein phosphorylation | peptide metabolic process | regulation of RNA metabolic process | viral process | nucleotide-excision repair, DNA gap filling | regulation of cellular response to growth factor stimulus | proteasome-mediated ubiquitin-dependent protein catabolic process | positive regulation of molecular function | protein polyubiquitination | cellular response to transforming growth factor beta stimulus | establishment of protein localization to membrane | activation of MAPK activity | protein-containing complex assembly | activation of immune response | nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | protein metabolic process | negative regulation of transforming growth factor beta receptor signaling pathway | positive regulation of protein modification process | response to organic substance | regulation of innate immune response | protein ubiquitination | MyD88-independent toll-like receptor signaling pathway | regulation of kinase activity | DNA metabolic process | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | cellular macromolecule catabolic process | nucleotide-excision repair, DNA incision | establishment of protein localization to organelle | cell surface receptor signaling pathway | DNA damage response, detection of DNA damage | metabolic process | nucleotide-excision repair | regulation of DNA-templated transcription in response to stress | regulation of RNA biosynthetic process | establishment of protein localization to endoplasmic reticulum | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | cellular protein localization | virion assembly | amide transport | positive regulation of cell death | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | regulation of mRNA catabolic process | gene expression | amide biosynthetic process | positive regulation of NF-kappaB transcription factor activity | positive regulation of programmed cell death | positive regulation of kinase activity | protein modification by small protein conjugation or removal | regulation of phosphate metabolic process | establishment of protein localization | positive regulation of MAPK cascade | intracellular receptor signaling pathway | ubiquitin-dependent protein catabolic process | transforming growth factor beta receptor signaling pathway | organonitrogen compound catabolic process | transcription-coupled nucleotide-excision repair | regulation of cell communication | negative regulation of signal transduction | transmembrane transport | signaling | regulation of transcription, DNA-templated | I-kappaB kinase/NF-kappaB signaling | protein localization | positive regulation of phosphorylation | cellular protein metabolic process | regulation of transcription from RNA polymerase II promoter in response to stress | cellular macromolecule localization | cellular macromolecule biosynthetic process | positive regulation of MAP kinase activity | protein targeting to membrane | regulation of transcription from RNA polymerase II promoter in response to hypoxia | organelle organization | cellular response to interleukin-1 | cellular protein modification process | negative regulation of transcription by RNA polymerase II | positive regulation of transcription, DNA-templated | DNA synthesis involved in DNA repair | MyD88-dependent toll-like receptor signaling pathway | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | chromosome organization | protein targeting | immune system process | cellular metabolic process | cellular response to organic substance | regulation of cell death | modification-dependent protein catabolic process | negative regulation of cell death | positive regulation of signaling | signal transduction | regulation of signaling | nucleotide-excision repair, preincision complex assembly | positive regulation of gene expression | cellular response to growth factor stimulus | macromolecule metabolic process | regulation of phosphorus metabolic process

GO Cellular Component

cytosolic ribosome | intracellular membrane-bounded organelle | endocytic vesicle membrane | host cell | organelle membrane | cytoplasmic vesicle | cell | organelle outer membrane | nuclear lumen | other organism cell | cytoplasm | intracellular organelle | ribosome | endoplasmic reticulum | endosome membrane | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | endomembrane system | endoplasmic reticulum membrane | nucleoplasm | plasma membrane | vacuole | ribonucleoprotein complex | vesicle | extracellular exosome | mitochondrion | small ribosomal subunit | lytic vacuole | endosome | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | mitochondrial outer membrane | vesicle membrane | mitochondrial envelope | lysosome | extracellular space | cell periphery | cytosolic small ribosomal subunit | membrane-enclosed lumen | outer membrane | mitochondrial membrane | cytosol | intracellular vesicle | endocytic vesicle | intracellular | lysosomal membrane | membrane | cytoplasmic vesicle membrane | vacuolar membrane