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QuickView for UBB;jsessionid=14068BBD14E9F85F0CC01BA459702EFC (gene)


Gene Symbol:
UBB Homo sapiens Homo sapiens
Full name:
ubiquitin B
Synonyms:
HEL-S-50, polyubiquitin-B, epididymis secretory protein Li 50, polyubiquitin B
Genomic Location:
Chr 17: 16225092-16226779
Description:
This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting ...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 17
17p11.2





GO Molecular Function

enzyme binding | ubiquitin-like protein ligase binding | protein tag | protein binding | ubiquitin protein ligase binding

GO Biological Process

positive regulation of immune response | protein modification by small protein removal | interstrand cross-link repair | nucleotide-binding oligomerization domain containing signaling pathway | cell morphogenesis | error-free translesion synthesis | cellular response to decreased oxygen levels | positive regulation of macromolecule biosynthetic process | peroxisome organization | microtubule-based transport | detection of stimulus | nucleotide-excision repair, DNA damage recognition | response to cytokine | response to interleukin-1 | neuron projection morphogenesis | immune response-regulating signaling pathway | intracellular signal transduction | positive regulation of apoptotic process | proteolysis | positive regulation of DNA-binding transcription factor activity | regulation of programmed cell death | translesion synthesis | establishment of localization | regulation of immune system process | regulation of transforming growth factor beta receptor signaling pathway | negative regulation of cellular process | regulation of MAP kinase activity | negative regulation of RNA biosynthetic process | cell differentiation | positive regulation of intrinsic apoptotic signaling pathway | nervous system development | cell part morphogenesis | neurogenesis | positive regulation of phosphate metabolic process | generation of neurons | membrane organization | intracellular transport | microtubule-based process | regulation of neuron death | innate immune response-activating signal transduction | positive regulation of cellular biosynthetic process | cellular process | positive regulation of signal transduction by p53 class mediator | toll-like receptor signaling pathway | organic substance catabolic process | establishment of organelle localization | localization | cell projection morphogenesis | proteolysis involved in cellular protein catabolic process | protein transport | regulation of mitochondrial membrane potential | negative regulation of signaling | neuron development | protein targeting to peroxisome | negative regulation of nucleic acid-templated transcription | global genome nucleotide-excision repair | positive regulation of protein kinase activity | macromolecule localization | negative regulation of apoptotic process | postreplication repair | response to hypoxia | regulation of proteolysis | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | establishment of localization in cell | negative regulation of cellular metabolic process | interspecies interaction between organisms | cytoskeleton-dependent intracellular transport | regulation of mRNA stability | regulation of immune response | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | catabolic process | organelle localization | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | cellular aromatic compound metabolic process | cellular component organization | protein deubiquitination | MAPK cascade | viral life cycle | response to transforming growth factor beta | response to stimulus | JNK cascade | positive regulation of innate immune response | positive regulation of immune system process | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | endosomal transport | regulation of cellular protein catabolic process | cellular response to hypoxia | response to stress | intracellular protein transport | organelle transport along microtubule | cellular nitrogen compound biosynthetic process | posttranscriptional regulation of gene expression | regulation of protein ubiquitination | anaphase-promoting complex-dependent catabolic process | protein-DNA complex assembly | activation of innate immune response | microtubule-based movement | cellular protein catabolic process | cellular localization | cellular nitrogen compound metabolic process | proteasomal protein catabolic process | immune response-activating signal transduction | nucleic acid phosphodiester bond hydrolysis | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | cellular component assembly | protein modification process | cellular biosynthetic process | macromolecule modification | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | cell-cell signaling | mitochondrion transport along microtubule | activation of protein kinase activity | cell surface receptor signaling pathway involved in cell-cell signaling | stress-activated protein kinase signaling cascade | DNA repair | intracellular transport of virus | regulation of nucleic acid-templated transcription | negative regulation of cellular response to transforming growth factor beta stimulus | regulation of membrane potential | system development | response to oxygen levels | nitrogen compound metabolic process | regulation of protein monoubiquitination | regulation of signal transduction | pattern recognition receptor signaling pathway | Wnt signaling pathway | multicellular organism development | regulation of MAPK cascade | phosphorus metabolic process | cellular response to DNA damage stimulus | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | nucleotide-excision repair, DNA incision, 5'-to lesion | regulation of intrinsic apoptotic signaling pathway | regulation of gene expression | DNA biosynthetic process | organic substance transport | cellular response to stress | protein catabolic process | regulation of signal transduction by p53 class mediator | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | positive regulation of protein monoubiquitination | error-prone translesion synthesis | cellular response to oxygen levels | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | enzyme linked receptor protein signaling pathway | interleukin-1-mediated signaling pathway | peptide transport | cytokine-mediated signaling pathway | negative regulation of cellular response to growth factor stimulus | positive regulation of intracellular signal transduction | regulation of RNA stability | vesicle-mediated transport | regulation of transcription by RNA polymerase II | protein localization to organelle | mitochondrion localization | cellular response to cytokine stimulus | biosynthetic process | stress-activated MAPK cascade | regulation of cellular protein metabolic process | TRIF-dependent toll-like receptor signaling pathway | aromatic compound biosynthetic process | phosphorylation | cellular protein-containing complex assembly | establishment of protein localization to peroxisome | regulation of apoptotic signaling pathway | protein phosphorylation | phosphate-containing compound metabolic process | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | transmembrane receptor protein serine/threonine kinase signaling pathway | regulation of protein metabolic process | positive regulation of signal transduction | regulation of protein phosphorylation | regulation of RNA metabolic process | viral process | nucleotide-excision repair, DNA gap filling | regulation of cellular response to growth factor stimulus | proteasome-mediated ubiquitin-dependent protein catabolic process | positive regulation of molecular function | protein polyubiquitination | cellular response to transforming growth factor beta stimulus | neuron differentiation | activation of MAPK activity | protein-containing complex assembly | activation of immune response | nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | protein metabolic process | negative regulation of transforming growth factor beta receptor signaling pathway | positive regulation of protein modification process | response to organic substance | positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator | regulation of innate immune response | protein ubiquitination | establishment of mitochondrion localization, microtubule-mediated | MyD88-independent toll-like receptor signaling pathway | regulation of kinase activity | DNA metabolic process | establishment of mitochondrion localization | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | cellular macromolecule catabolic process | nucleotide-excision repair, DNA incision | establishment of protein localization to organelle | anatomical structure development | cell surface receptor signaling pathway | DNA damage response, detection of DNA damage | cell projection organization | metabolic process | nucleotide-excision repair | regulation of DNA-templated transcription in response to stress | regulation of protein catabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | transport along microtubule | regulation of proteasomal protein catabolic process | cellular protein localization | virion assembly | amide transport | positive regulation of cell death | nucleobase-containing compound metabolic process | neuron projection development | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | regulation of mRNA catabolic process | positive regulation of NF-kappaB transcription factor activity | positive regulation of programmed cell death | positive regulation of kinase activity | protein modification by small protein conjugation or removal | regulation of phosphate metabolic process | establishment of protein localization | positive regulation of MAPK cascade | intracellular receptor signaling pathway | ubiquitin-dependent protein catabolic process | transforming growth factor beta receptor signaling pathway | organonitrogen compound catabolic process | transcription-coupled nucleotide-excision repair | regulation of cell communication | negative regulation of signal transduction | transmembrane transport | signaling | regulation of transcription, DNA-templated | cell development | I-kappaB kinase/NF-kappaB signaling | protein localization | positive regulation of phosphorylation | cellular protein metabolic process | regulation of transcription from RNA polymerase II promoter in response to stress | anatomical structure morphogenesis | cellular macromolecule localization | cellular macromolecule biosynthetic process | positive regulation of MAP kinase activity | regulation of transcription from RNA polymerase II promoter in response to hypoxia | regulation of intrinsic apoptotic signaling pathway by p53 class mediator | developmental process | organelle organization | cellular response to interleukin-1 | cellular protein modification process | negative regulation of transcription by RNA polymerase II | positive regulation of transcription, DNA-templated | DNA synthesis involved in DNA repair | MyD88-dependent toll-like receptor signaling pathway | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | chromosome organization | protein targeting | immune system process | cellular metabolic process | cellular response to organic substance | regulation of cell death | modification-dependent protein catabolic process | negative regulation of cell death | positive regulation of protein ubiquitination | positive regulation of apoptotic signaling pathway | positive regulation of signaling | signal transduction | regulation of signaling | nucleotide-excision repair, preincision complex assembly | positive regulation of gene expression | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | neuron projection | endocytic vesicle membrane | somatodendritic compartment | host cell | organelle membrane | cytoplasmic vesicle | cell body | cell | organelle outer membrane | nuclear lumen | neuronal cell body | other organism cell | cytoplasm | intracellular organelle | endoplasmic reticulum | endosome membrane | nuclear outer membrane-endoplasmic reticulum membrane network | cell projection | endomembrane system | endoplasmic reticulum membrane | nucleoplasm | plasma membrane | vesicle | extracellular exosome | mitochondrion | endosome | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | mitochondrial outer membrane | vesicle membrane | mitochondrial envelope | extracellular space | cell periphery | membrane-enclosed lumen | outer membrane | mitochondrial membrane | cytosol | intracellular vesicle | endocytic vesicle | intracellular | membrane | cytoplasmic vesicle membrane