QuickView for UCP3 (gene)

Gene Symbol:

UCP3 Homo sapiens

Full name:

uncoupling protein 3

Synonyms:

SLC25A9, mitochondrial uncoupling protein 3, solute carrier family 25 member 9, uncoupling protein 3 (mitochondrial, proton carrier)

Genomic Location:

Chr 11: 73388985-73397778

Description:

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membra...

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Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NKX25_01 ,  TTTGCAC_MIR19A_MIR19B ,  TCANNTGAY_SREBP1_01 ,  TTGCACT_MIR130A_MIR301_MIR130B ,  TGCACTG_MIR148A_MIR152_MIR148B ,  AP4_01 ,  TGACAGNY_MEIS1_01

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-189 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-370

Cytogenetic Map:

11q13.4

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