QuickView for UGDH (gene)
- Gene Symbol:
- UGDH
Homo sapiens - Full name:
- UDP-glucose 6-dehydrogenase
- Synonyms:
- GDH, UDP-GlcDH, UDPGDH, UGD, UDP-glucose 6-dehydrogenase, UDP-Glc dehydrogenase, UDP-glucose dehydrogenase, uridine diphospho-glucose dehydrogenase
- Genomic Location:
- Chr 4: 39176770-39205606
- Description:
-
The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and can...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Danio rerio , Bos taurus , Gallus gallus , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: miRecords):
- Cytogenetic Map:
-
4p14
GO Molecular Function
oxidoreductase activity, acting on CH-OH group of donors | UDP-glucose 6-dehydrogenase activity | cofactor binding | nucleotide binding | coenzyme binding | catalytic activity | electron transfer activity | organic cyclic compound binding | NAD binding | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | heterocyclic compound binding | oxidoreductase activity | small molecule binding
GO Biological Process
oxidoreductase activity, acting on CH-OH group of donors | UDP-glucuronate biosynthetic process | nucleotide-sugar biosynthetic process | UDP-glucose 6-dehydrogenase activity | generation of precursor metabolites and energy | cellular process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | glycosaminoglycan biosynthetic process | UDP-glucose metabolic process | cellular nitrogen compound biosynthetic process | electron transport chain | cellular nitrogen compound metabolic process | carbohydrate derivative biosynthetic process | cellular biosynthetic process | UDP-glucuronate metabolic process | embryo development | nitrogen compound metabolic process | multicellular organism development | phosphorus metabolic process | electron transfer activity | small molecule metabolic process | nucleobase-containing small molecule metabolic process | biosynthetic process | aromatic compound biosynthetic process | gastrulation with mouth forming second | embryonic morphogenesis | carboxylic acid metabolic process | anatomical structure development | metabolic process | oxidation-reduction process | nucleobase-containing compound metabolic process | nucleotide-sugar metabolic process | organic substance metabolic process | organic acid metabolic process | anatomical structure morphogenesis | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | developmental process | carbohydrate derivative metabolic process | heterocycle metabolic process | gastrulation | cellular metabolic process | oxidoreductase activity | glycosaminoglycan metabolic process | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nucleoplasm | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | extracellular space | membrane-enclosed lumen | cytosol | intracellular
