QuickView for UGP2;jsessionid=A230E78121AA7A91C54FDDBD660DDB57 (gene)

Gene Symbol:

UGP2 Homo sapiens

Full name:

UDP-glucose pyrophosphorylase 2

Synonyms:

UDPG, UDPGP, UDPGP2, UGP1, UGPP1, UGPP2, pHC379, UTP--glucose-1-phosphate uridylyltransferase, UDP-glucose diphosphorylase, UDP-glucose pyrophosphorylase 1, UGPase 2, UTP--glucose-1-phosphate uridylyltransferase 2, UTP-glucose-1-phosphate uridyltransferase, Uridyl diphosphate glucose pyrophosphorylase-1, testis tissue sperm-binding protein Li 58p, uridyl diphosphate glucose pyrophosphorylase 2

Genomic Location:

Chr 2: 63921602-63972200

Description:

The enzyme encoded by this gene is an important intermediary in mammalian carbohydrate interconversions. It transfers a glucose moiety from glucose-1-phosphate to MgUTP and forms UDP-glucose and MgPPi. In liver and muscle tissue, UDP-glucose is a direct precursor of glycogen; in lactating mammary gland it is converted to UDP-galactose which is then...

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The enzyme encoded by this gene is an important intermediary in mammalian carbohydrate interconversions. It transfers a glucose moiety from glucose-1-phosphate to MgUTP and forms UDP-glucose and MgPPi. In liver and muscle tissue, UDP-glucose is a direct precursor of glycogen; in lactating mammary gland it is converted to UDP-galactose which is then converted to lactose. The eukaryotic enzyme has no significant sequence similarity to the prokaryotic enzyme. Two transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGACCTY_ERR1_Q2 ,  GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367 ,  GGGAGGRR_MAZ_Q6 ,  NFY_Q6_01 ,  ALPHACP1_01 ,  SP1_Q4_01 ,  PXR_Q2 ,  GGGCGGR_SP1_Q6 ,  CEBPB_02 ,  NFY_Q6 ,  SP1_Q6 ,  SP1_Q6_01 ,  AACTTT_UNKNOWN

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-137

miRNA binding sites
(Source: miRecords):

hsa-miR-15a/hsa-miR-16 Targeted Genes

Cytogenetic Map:

2p15

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