QuickView for UGT1A10 (gene)

Gene Symbol:

UGT1A10 Homo sapiens

Full name:

UDP glucuronosyltransferase family 1 member A10

Synonyms:

UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J, UDP-glucuronosyltransferase 1-10, UDP glucuronosyltransferase 1 family, polypeptide A10, UDP glycosyltransferase 1 family, polypeptide A10, UDP-glucuronosyltransferase 1-J, UDP-glucuronosyltransferase 1A10, UDPGT 1-10

Genomic Location:

Chr 2: 234209862-234346690

Description:

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique...

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This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity on mycophenolic acid, coumarins, and quinolines.

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External Links:

Entrez Gene

Cytogenetic Map:

2q37.1

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