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QuickView for UGT1A4 (gene)


Gene Symbol:
UGT1A4 Homo sapiens Homo sapiens
Full name:
UDP glucuronosyltransferase family 1 member A4
Synonyms:
HUG-BR2, UDPGT, UDPGT 1-4, UGT-1D, UGT1-04, UGT1.4, UGT1A4S, UGT1D, UDP-glucuronosyltransferase 1-4, UDP glucuronosyltransferase 1 family, polypeptide A4, UDP glycosyltransferase 1 family, polypeptide A4, UDP-glucuronosyltransferase 1 family polypeptide A4s, UDP-glucuronosyltransferase 1-D, UDP-glucuronosyltransferase 1A4, bilirubin UDP-glucuronosyltransferase isozyme 2, bilirubin-specific UDPGT isozyme 2
Genomic Location:
Chr 2: 234292177-234346684
Description:
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique...
Orthologs:
Macaca mulatta
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 2
2q37.1


Transcripts Names
NM_007120
Protein Names
Q5DT00
P22310
B2R937



GO Molecular Function

isoprenoid binding | retinoid binding | carboxylic acid binding | lipid binding | UDP-glycosyltransferase activity | catalytic activity | anion binding | identical protein binding | transferase activity, transferring glycosyl groups | protein heterodimerization activity | ion binding | protein binding | protein homodimerization activity | protein dimerization activity | transferase activity, transferring hexosyl groups | transferase activity | retinoic acid binding | glucuronosyltransferase activity | organic acid binding | small molecule binding

GO Biological Process

cellular process | organic substance catabolic process | heme metabolic process | porphyrin-containing compound metabolic process | xenobiotic metabolic process | catabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | heme catabolic process | response to stimulus | monocarboxylic acid metabolic process | cellular response to xenobiotic stimulus | cellular nitrogen compound metabolic process | cofactor metabolic process | nitrogen compound metabolic process | monosaccharide metabolic process | small molecule metabolic process | glucuronate metabolic process | flavonoid metabolic process | carbohydrate metabolic process | response to xenobiotic stimulus | aromatic compound catabolic process | carboxylic acid metabolic process | metabolic process | bilirubin conjugation | organic substance metabolic process | pigment metabolic process | cellular glucuronidation | organonitrogen compound catabolic process | organic acid metabolic process | flavonoid glucuronidation | heterocycle metabolic process | cellular metabolic process | xenobiotic glucuronidation

GO Cellular Component

integral component of membrane | intracellular membrane-bounded organelle | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | nuclear outer membrane-endoplasmic reticulum membrane network | endomembrane system | endoplasmic reticulum membrane | membrane-bounded organelle | organelle | intracellular | membrane