QuickView for UGT1A7;jsessionid=E46B00E87E2D02AAF59893E8CE712CF4 (gene)

Gene Symbol:

UGT1A7 Homo sapiens

Full name:

UDP glucuronosyltransferase family 1 member A7

Synonyms:

UDPGT, UDPGT 1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G, UDP-glucuronosyltransferase 1-7, UDP glucuronosyltransferase 1 family, polypeptide A7, UDP glycosyltransferase 1 family, polypeptide A7, UDP-glucuronosyltransferase 1 family polypeptide A7s, UDP-glucuronosyltransferase 1-G, UDP-glucuronosyltransferase 1A7

Genomic Location:

Chr 2: 234255323-234346684

Description:

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique...

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This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has moderate glucuronidase activity with phenols.

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Orthologs:

Macaca mulatta ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CAGCTG_AP4_Q5

Cytogenetic Map:

2q37.1

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