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QuickView for UGT1A8;jsessionid=B367FD51CC1DC67C15C5FB32BF298A4E (gene)


Gene Symbol:
UGT1A8 Homo sapiens Homo sapiens
Full name:
UDP glucuronosyltransferase family 1 member A8
Synonyms:
UDPGT, UDPGT 1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H, UDP-glucuronosyltransferase 1-8, UDP glucuronosyltransferase 1 family, polypeptide A8, UDP glycosyltransferase 1 family, polypeptide A8, UDP-glucuronosyltransferase 1 family polypeptide A8s, UDP-glucuronosyltransferase 1-H, UDP-glucuronosyltransferase 1A8
Genomic Location:
Chr 2: 234191030-234346684
Description:
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique...
Orthologs:
Mus musculus Rattus norvegicus
External Links:
Entrez Gene
Cytogenetic Map:
chr 2
2q37.1


Transcripts Names
NM_019076



GO Molecular Function

fatty acid binding | isoprenoid binding | retinoid binding | carboxylic acid binding | lipid binding | enzyme inhibitor activity | UDP-glycosyltransferase activity | molecular function regulator | catalytic activity | anion binding | identical protein binding | transferase activity, transferring glycosyl groups | protein heterodimerization activity | ion binding | organic cyclic compound binding | protein binding | protein homodimerization activity | protein dimerization activity | transferase activity, transferring hexosyl groups | transferase activity | enzyme regulator activity | retinoic acid binding | steroid binding | glucuronosyltransferase activity | organic acid binding | small molecule binding

GO Biological Process

negative regulation of cellular process | cellular process | negative regulation of cellular metabolic process | regulation of cellular process | regulation of metabolic process | xenobiotic metabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | cellular lipid metabolic process | response to stimulus | enzyme inhibitor activity | monocarboxylic acid metabolic process | cellular response to xenobiotic stimulus | flavone metabolic process | negative regulation of metabolic process | regulation of steroid metabolic process | molecular function regulator | retinoid metabolic process | negative regulation of catalytic activity | regulation of catalytic activity | lipid metabolic process | regulation of hormone levels | monosaccharide metabolic process | small molecule metabolic process | regulation of fatty acid metabolic process | glucuronate metabolic process | flavonoid metabolic process | carbohydrate metabolic process | response to xenobiotic stimulus | regulation of cellular metabolic process | retinoic acid metabolic process | carboxylic acid metabolic process | negative regulation of lipid metabolic process | metabolic process | organic substance metabolic process | pigment metabolic process | diterpenoid metabolic process | cellular glucuronidation | fatty acid metabolic process | steroid metabolic process | coumarin metabolic process | negative regulation of molecular function | organic acid metabolic process | enzyme regulator activity | hormone metabolic process | regulation of cellular ketone metabolic process | isoprenoid metabolic process | negative regulation of steroid metabolic process | flavonoid glucuronidation | heterocycle metabolic process | regulation of lipid metabolic process | cellular metabolic process | xenobiotic glucuronidation | negative regulation of fatty acid metabolic process

GO Cellular Component

integral component of membrane | intracellular membrane-bounded organelle | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | nuclear outer membrane-endoplasmic reticulum membrane network | endomembrane system | endoplasmic reticulum membrane | membrane-bounded organelle | organelle | intracellular | membrane