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QuickView for UGT8;jsessionid=4043CCA06D4B5FF30FD8A73B5ADE52AD (gene)


Gene Symbol:
UGT8 Homo sapiens Homo sapiens
Full name:
UDP glycosyltransferase 8
Synonyms:
CGT, UGT4, 2-hydroxyacylsphingosine 1-beta-galactosyltransferase, UDP-galactose-ceramide galactosyltransferase, ceramide UDP-galactosyltransferase, cerebroside synthase, uridine diphosphate glycosyltransferase 8
Genomic Location:
Chr 4: 115762972-115817201
Description:
The protein encoded by this gene belongs to the UDP-glycosyltransferase family. It catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central and peripheral nervous systems. Alternatively spliced transcript variants have bee...
Orthologs:
Mus musculus Rattus norvegicus C. elegans Macaca mulatta Bos taurus Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 4
4q26





GO Molecular Function

UDP-galactosyltransferase activity | N-acylsphingosine galactosyltransferase activity | UDP-glycosyltransferase activity | catalytic activity | transferase activity, transferring glycosyl groups | transferase activity, transferring hexosyl groups | transferase activity | galactosyltransferase activity | UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity

GO Biological Process

cell morphogenesis | neuron projection morphogenesis | glycosphingolipid metabolic process | glycolipid biosynthetic process | cell differentiation | protein localization to axon | nervous system development | cell part morphogenesis | neurogenesis | generation of neurons | cellular process | peripheral nervous system development | localization | axon ensheathment | cell projection morphogenesis | neuron development | macromolecule localization | sphingolipid metabolic process | paranodal junction assembly | galactosylceramide biosynthetic process | cell junction assembly | cellular component organization | cellular lipid metabolic process | glycosphingolipid biosynthetic process | cellular nitrogen compound biosynthetic process | ceramide metabolic process | ensheathment of neurons | sphingolipid biosynthetic process | cellular localization | cellular nitrogen compound metabolic process | carbohydrate derivative biosynthetic process | cellular component assembly | cellular biosynthetic process | system development | nitrogen compound metabolic process | myelination | multicellular organism development | lipid metabolic process | galactosylceramide metabolic process | cellular amide metabolic process | glycolipid metabolic process | biosynthetic process | lipid biosynthetic process | glycosylceramide metabolic process | neuron differentiation | anatomical structure development | cell projection organization | metabolic process | membrane lipid metabolic process | cell-cell junction assembly | cellular protein localization | neuron projection development | organic substance metabolic process | amide biosynthetic process | cytoskeleton organization | anatomical structure formation involved in morphogenesis | cell development | protein localization | anatomical structure morphogenesis | cellular macromolecule localization | developmental process | organelle organization | myelin assembly | carbohydrate derivative metabolic process | central nervous system development | cellular metabolic process | ceramide biosynthetic process | protein localization to paranode region of axon | multicellular organismal process | cell-cell junction organization

GO Cellular Component

integral component of membrane | intracellular membrane-bounded organelle | cell | intrinsic component of membrane | intracellular organelle | plasma membrane | membrane-bounded organelle | organelle | cell periphery | intracellular | membrane