QuickView for UNC5C (gene)

Gene Symbol:

UNC5C Homo sapiens

Full name:

unc-5 netrin receptor C

Synonyms:

UNC5H3, netrin receptor UNC5C, protein unc-5 homolog 3, protein unc-5 homolog C, unc-5 homolog 3, unc-5 homolog C, unc5 (C.elegans homolog) c

Genomic Location:

Chr 4: 96308712-96689185

Description:

This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of rec...

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This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  SMTTTTGT_UNKNOWN ,  TFIIA_Q6 ,  ZIC1_01 ,  GGGATGC_MIR3245P ,  AP3_Q6 ,  E4BP4_01 ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  MEIS1BHOXA9_01 ,  MAF_Q6 ,  TTAYRTAA_E4BP4_01 ,  GTACAGG_MIR486 ,  EGR_Q6 ,  CREBP1_01 ,  YKACATTT_UNKNOWN ,  GACAGGG_MIR339 ,  ISRE_01 ,  TGACATY_UNKNOWN ,  CTAGGAA_MIR384 ,  HOX13_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-125 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-324-5p ,  Predicted Gene Targets for miR-339 ,  Predicted Gene Targets for miR-384 ,  Predicted Gene Targets for miR-486

Cytogenetic Map:

4q22.3

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