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QuickView for UNC93B1 (gene)


Gene Symbol:
UNC93B1 Homo sapiens Homo sapiens
Full name:
unc-93 homolog B1, TLR signaling regulator
Synonyms:
IIAE1, UNC93, UNC93B, Unc-93B1, protein unc-93 homolog B1, unc-93 homolog B1, unc-93 related protein, unc93 homolog B1
Genomic Location:
Chr 11: 67515151-67528169
Description:
This gene encodes a protein that is involved in innate and adaptive immune response by regulating toll-like receptor signaling. The encoded protein traffics nucleotide sensing toll-like receptors to the endolysosome from the endoplasmic reticulum. Deficiency of the encoded protein has been associated with herpes simplex encephalitis.
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Macaca mulatta Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 11
11q13.2


Transcripts Names
NM_030930
XM_011545291
XM_011545290
Protein Names
O95764
Q710D4
Q569H6
Q9H1C4



GO Molecular Function

signaling receptor binding | Toll-like receptor binding | protein binding

GO Biological Process

positive regulation of immune response | adaptive immune response | response to virus | immune response-regulating signaling pathway | defense response to other organism | establishment of localization | regulation of immune system process | defense response | intracellular transport | innate immune response-activating signal transduction | cellular process | toll-like receptor signaling pathway | localization | protein transport | macromolecule localization | toll-like receptor 7 signaling pathway | establishment of localization in cell | regulation of immune response | regulation of cellular process | response to stimulus | positive regulation of innate immune response | positive regulation of immune system process | response to stress | intracellular protein transport | activation of innate immune response | cellular localization | immune response-activating signal transduction | response to external biotic stimulus | pattern recognition receptor signaling pathway | organic substance transport | defense response to virus | peptide transport | cell communication | toll-like receptor 9 signaling pathway | activation of immune response | regulation of innate immune response | cellular protein localization | amide transport | immune response | establishment of protein localization | toll-like receptor 3 signaling pathway | signaling | protein localization | cellular macromolecule localization | response to biotic stimulus | innate immune response | immune system process | response to other organism | signal transduction

GO Cellular Component

integral component of membrane | intracellular membrane-bounded organelle | organelle membrane | cytoplasmic vesicle | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | Golgi apparatus | nuclear outer membrane-endoplasmic reticulum membrane network | endomembrane system | endoplasmic reticulum membrane | vacuole | vesicle | lytic vacuole | Golgi membrane | endosome | membrane-bounded organelle | organelle | lysosome | early phagosome | intracellular vesicle | endocytic vesicle | intracellular | membrane | phagocytic vesicle