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QuickView for USP7 (gene)


Gene Symbol:
USP7 Homo sapiens Homo sapiens
Full name:
ubiquitin specific peptidase 7
Synonyms:
HAUSP, TEF1, ubiquitin carboxyl-terminal hydrolase 7, Herpes virus-associated ubiquitin-specific protease, deubiquitinating enzyme 7, ubiquitin specific peptidase 7 (herpes virus-associated), ubiquitin specific protease 7 (herpes virus-associated), ubiquitin thioesterase 7, ubiquitin-specific-processing protease 7
Genomic Location:
Chr 16: 8893452-8964842
Description:
The protein encoded by this gene belongs to the peptidase C19 family, which includes ubiquitinyl hydrolases. This protein deubiquitinates target proteins such as p53 (a tumor suppressor protein) and WASH (essential for endosomal protein recycling), and regulates their activities by counteracting the opposing ubiquitin ligase activity of proteins su...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 16
16p13.2





GO Molecular Function

Lys48-specific deubiquitinase activity | enzyme binding | thiol-dependent ubiquitinyl hydrolase activity | hydrolase activity | cysteine-type peptidase activity | catalytic activity | ubiquitin-like protein ligase binding | p53 binding | thiol-dependent ubiquitin-specific protease activity | cysteine-type endopeptidase activity | protein binding | ubiquitinyl hydrolase activity | transcription factor binding | ubiquitin protein ligase binding | endopeptidase activity | peptidase activity | protein C-terminus binding

GO Biological Process

protein modification by small protein removal | proteolysis | protein stabilization | negative regulation of cellular process | histone modification | regulation of organelle organization | negative regulation of proteolysis | cellular process | organic substance catabolic process | negative regulation of ubiquitin-dependent protein catabolic process | proteolysis involved in cellular protein catabolic process | chromatin organization | regulation of proteolysis | Lys48-specific deubiquitinase activity | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | interspecies interaction between organisms | regulation of cellular process | regulation of metabolic process | catabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | cellular component organization | protein deubiquitination | thiol-dependent ubiquitinyl hydrolase activity | negative regulation of cellular protein catabolic process | regulation of telomere capping | response to stimulus | regulation of cellular protein catabolic process | response to stress | cellular protein catabolic process | cellular nitrogen compound metabolic process | protein K48-linked deubiquitination | negative regulation of metabolic process | protein modification process | macromolecule modification | cysteine-type peptidase activity | DNA repair | regulation of nucleic acid-templated transcription | negative regulation of NF-kappaB transcription factor activity | nitrogen compound metabolic process | regulation of protein stability | multicellular organism development | cellular response to DNA damage stimulus | regulation of telomere maintenance | negative regulation of proteasomal ubiquitin-dependent protein catabolic process | regulation of gene expression | cellular response to stress | protein catabolic process | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | negative regulation of DNA-binding transcription factor activity | regulation of cellular protein metabolic process | positive regulation of DNA demethylation | thiol-dependent ubiquitin-specific protease activity | regulation of cellular metabolic process | regulation of protein metabolic process | cysteine-type endopeptidase activity | regulation of RNA metabolic process | viral process | regulation of proteasomal ubiquitin-dependent protein catabolic process | protein metabolic process | DNA metabolic process | histone H2B conserved C-terminal lysine deubiquitination | regulation of DNA-binding transcription factor activity | cellular macromolecule catabolic process | anatomical structure development | metabolic process | nucleotide-excision repair | regulation of protein catabolic process | regulation of RNA biosynthetic process | regulation of proteasomal protein catabolic process | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of cellular protein metabolic process | protein modification by small protein conjugation or removal | regulation of chromosome organization | maintenance of DNA methylation | ubiquitin-dependent protein catabolic process | negative regulation of protein catabolic process | negative regulation of protein metabolic process | organonitrogen compound catabolic process | transcription-coupled nucleotide-excision repair | negative regulation of molecular function | covalent chromatin modification | regulation of transcription, DNA-templated | endopeptidase activity | cellular protein metabolic process | positive regulation of DNA metabolic process | developmental process | organelle organization | cellular protein modification process | heterocycle metabolic process | positive regulation of metabolic process | chromosome organization | cellular metabolic process | peptidase activity | modification-dependent protein catabolic process | histone deubiquitination | regulation of ubiquitin-dependent protein catabolic process | negative regulation of proteolysis involved in cellular protein catabolic process | regulation of cellular component organization | monoubiquitinated protein deubiquitination | macromolecule metabolic process | multicellular organismal process | negative regulation of proteasomal protein catabolic process

GO Cellular Component

chromosome | intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nuclear body | protein-containing complex | PML body | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular