QuickView for VAMP2 (gene)

Gene Symbol:

VAMP2 Homo sapiens

Full name:

vesicle associated membrane protein 2

Synonyms:

SYB2, VAMP-2, vesicle-associated membrane protein 2, synaptobrevin 2

Genomic Location:

Chr 17: 8003189-8007017

Description:

The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is...

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The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFMUE1_Q6 ,  CACTGCC_MIR34A_MIR34C_MIR449 ,  FXR_Q3 ,  TFIIA_Q6 ,  TGANTCA_AP1_C ,  PR_01 ,  YGTCCTTGR_UNKNOWN ,  CTATGCA_MIR153 ,  TTTGTAG_MIR520D ,  FXR_IR1_Q6 ,  ATGTACA_MIR493 ,  AGGAGTG_MIR483 ,  TGACCTY_ERR1_Q2 ,  GGATCCG_MIR127 ,  ACATTCC_MIR1_MIR206 ,  GGGYGTGNY_UNKNOWN ,  ATGCTGG_MIR338 ,  TTGGGAG_MIR150 ,  GTGACGY_E4F1_Q6 ,  CAGGTG_E12_Q6 ,  AGCTCCT_MIR28 ,  SP1_Q4_01 ,  EGR_Q6 ,  CREB_02 ,  GGCNKCCATNK_UNKNOWN ,  ACTGCCT_MIR34B ,  AAGWWRNYGGC_UNKNOWN ,  ACTGAAA_MIR30A3P_MIR30E3P ,  TCCAGAT_MIR5165P ,  TGCCAAR_NF1_Q6 ,  SP1_Q6 ,  OCT1_06 ,  RORA1_01 ,  MYOGENIN_Q6 ,  T3R_Q6 ,  CTTTGT_LEF1_Q2 ,  EGR1_01 ,  SP1_Q6_01 ,  ERR1_Q2 ,  TGACCTTG_SF1_Q6 ,  TATTATA_MIR374 ,  CP2_01 ,  SP1_Q2_01 ,  TAXCREB_01 ,  SF1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-127 ,  Predicted Gene Targets for miR-133 ,  Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-150 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-28 ,  Predicted Gene Targets for miR-30-3p ,  Predicted Gene Targets for miR-325 ,  Predicted Gene Targets for miR-338 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-34b ,  Predicted Gene Targets for miR-369-3p ,  Predicted Gene Targets for miR-377 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-374 ,  Predicted Gene Targets for miR-409-5p ,  Predicted Gene Targets for miR-410 ,  Predicted Gene Targets for miR-491 ,  Predicted Gene Targets for miR-493-5p

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Cytogenetic Map:

17p13.1

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