QuickView for VDR (gene)

Gene Symbol:

VDR Homo sapiens

Full name:

vitamin D receptor

Synonyms:

NR1I1, PPP1R163, vitamin D3 receptor, 1,25-dihydroxyvitamin D3 receptor, nuclear receptor subfamily 1 group I member 1, protein phosphatase 1, regulatory subunit 163, vitamin D (1,25- dihydroxyvitamin D3) receptor, vitamin D nuclear receptor variant 1

Genomic Location:

Chr 12: 46521587-46585081

Description:

This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear h...

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This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

MYOD_Q6_01 ,  AP1_C ,  TGANTCA_AP1_C ,  GCANCTGNY_MYOD_Q6 ,  YNTTTNNNANGCARM_UNKNOWN ,  SRY_01 ,  AP1_Q6 ,  E2A_Q2 ,  CAGGTG_E12_Q6 ,  AP1_01 ,  CTCAGGG_MIR125B_MIR125A ,  AP1FJ_Q2 ,  BACH2_01 ,  AP1_Q4 ,  TTGTTT_FOXO4_01 ,  CHOP_01 ,  AAAYRNCTG_UNKNOWN ,  SMAD4_Q6 ,  AGGGCAG_MIR18A ,  AP1_Q2 ,  CDC5_01 ,  AP1_Q4_01 ,  LMO2COM_01 ,  TGASTMAGC_NFE2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-125

Cytogenetic Map:

12q13.11

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