QuickView for VEGF-A (gene)

Gene Symbol:

Vegfa Rattus norvegicus

Full name:

vascular endothelial growth factor A

Synonyms:

VEGF-A, VEGF111, VEGF164, VPF, Vegf, vascular endothelial growth factor A, vascular permeability factor

Genomic Location:

Chr 9: 10521744-10534184

Description:

This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abno...

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This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site.

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Orthologs:

Homo sapiens ,  Mus musculus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

E47_01 ,  AP4_01 ,  AACTTT_UNKNOWN ,  SP1_01 ,  E4BP4_01 ,  IK2_01 ,  TAXCREB_01 ,  COUP_01 ,  CEBP_C ,  EGR1_01 ,  EGR3_01 ,  EGR2_01 ,  CHOP_01 ,  MIF1_01 ,  RFX1_01 ,  CCAWNWWNNNGGC_UNKNOWN ,  MYCMAX_B ,  ZF5_B ,  VDR_Q3 ,  ZIC1_01 ,  HIF1_Q5 ,  AP2ALPHA_01 ,  CDC5_01 ,  PPARA_02 ,  EFC_Q6 ,  FXR_Q3 ,  MTF1_Q4 ,  HEB_Q6 ,  FXR_IR1_Q6 ,  AHR_Q5 ,  SMAD_Q6 ,  HIF1_Q3 ,  GGARNTKYCCA_UNKNOWN ,  AP2_Q6_01 ,  AP4_Q6_01 ,  ER_Q6_02 ,  DR3_Q4 ,  AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  CACTGCC_MIR34A_MIR34C_MIR449 ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  ACATTCC_MIR1_MIR206 ,  CTCAGGG_MIR125B_MIR125A ,  CACTTTG_MIR520G_MIR520H ,  GTGGGTGK_UNKNOWN ,  TCTGATC_MIR383 ,  GTGTGAG_MIR342 ,  CTACTGT_MIR199A ,  TTGGGAG_MIR150 ,  AAACCAC_MIR140 ,  CCCACAT_MIR2993P ,  ATGAAGG_MIR205 ,  TCTCTCC_MIR185 ,  TCTGATA_MIR361 ,  RNCTGNYNRNCTGNY_UNKNOWN ,  ACTGCCT_MIR34B ,  RNGTGGGC_UNKNOWN ,  CAGTCAC_MIR134 ,  ATTCTTT_MIR186 ,  TGTGTGA_MIR377 ,  TAATAAT_MIR126 ,  TGGNNNNNNKCCAR_UNKNOWN ,  TTANTCA_UNKNOWN ,  WGTTNNNNNAAA_UNKNOWN ,  YGCGYRCGC_UNKNOWN ,  TGANTCA_AP1_C ,  CAGCTG_AP4_Q5 ,  TGACCTY_ERR1_Q2 ,  TTCNRGNNNNTTC_HSF_Q6 ,  GGGAGGRR_MAZ_Q6 ,  RYTGCNNRGNAAC_MIF1_01 ,  GCANCTGNY_MYOD_Q6 ,  TGGAAA_NFAT_Q4_01 ,  GGGCGGR_SP1_Q6

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