QuickView for VHR (gene)

Gene Symbol:

DUSP3 Homo sapiens

Full name:

dual specificity phosphatase 3

Synonyms:

VHR, dual specificity protein phosphatase 3, dual specificity protein phosphatase VHR, serine/threonine specific protein phosphatase, vaccinia H1-related phosphatase, vaccinia virus phosphatase VH1-related

Genomic Location:

Chr 17: 39199015-39211872

Description:

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38...

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The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

HNF4ALPHA_Q6 ,  TCANNTGAY_SREBP1_01 ,  TGGNNNNNNKCCAR_UNKNOWN ,  SMAD3_Q6 ,  YGACNNYACAR_UNKNOWN ,  CTATGCA_MIR153 ,  CAGTGTT_MIR141_MIR200A ,  COUP_01 ,  TGACCTY_ERR1_Q2 ,  HNF4_DR1_Q3 ,  TGAYRTCA_ATF3_Q6 ,  HNF4_01 ,  RYTGCNWTGGNR_UNKNOWN ,  TTGGGAG_MIR150 ,  GGATTA_PITX2_Q2 ,  RFX1_02 ,  CAGGTG_E12_Q6 ,  DR1_Q3 ,  HNF4_Q6 ,  ATF3_Q6 ,  GGGCGGR_SP1_Q6 ,  CAGCAGG_MIR370 ,  ATF1_Q6 ,  CTGCAGY_UNKNOWN ,  ER_Q6_02 ,  TGACATY_UNKNOWN ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  ER_Q6 ,  GTTRYCATRR_UNKNOWN ,  HNF4_01_B ,  OLF1_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-150 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-370 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-384

Cytogenetic Map:

17q21.31

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