QuickView for VKORC1 (gene)

Gene Symbol:

VKORC1 Homo sapiens

Full name:

vitamin K epoxide reductase complex subunit 1

Synonyms:

EDTP308, MST134, MST576, VKCFD2, VKOR, vitamin K epoxide reductase complex subunit 1, phylloquinone epoxide reductase, vitamin K dependent clotting factors deficiency 2, vitamin K1 2,3-epoxide reductase subunit 1, vitamin K1 epoxide reductase (warfarin-sensitive)

Genomic Location:

Chr 16: 31009676-31013777

Description:

This gene encodes the catalytic subunit of the vitamin K epoxide reductase complex, which is responsible for the reduction of inactive vitamin K 2,3-epoxide to active vitamin K in the endoplasmic reticulum membrane. Vitamin K is a required co-factor for carboxylation of glutamic acid residues by vitamin K-dependent gamma-carboxylase in blood-clotti...

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This gene encodes the catalytic subunit of the vitamin K epoxide reductase complex, which is responsible for the reduction of inactive vitamin K 2,3-epoxide to active vitamin K in the endoplasmic reticulum membrane. Vitamin K is a required co-factor for carboxylation of glutamic acid residues by vitamin K-dependent gamma-carboxylase in blood-clotting enzymes. Allelic variation in this gene is associated with vitamin k-dependent clotting factors combined deficiency of 2, and increased resistance or sensitivity to warfarin, an inhibitor of vitamin K epoxide reductase. Pseudogenes of this gene are located on chromosomes 1 and X. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Danio rerio ,  Gallus gallus ,  Bos taurus ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TCCCRNNRTGC_UNKNOWN ,  ACTAYRNNNCCCR_UNKNOWN

Cytogenetic Map:

16p11.2

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