QuickView for VPS35;jsessionid=9CAD6E748DF0CE512A18DECAAE86D165 (gene)

Gene Symbol:

VPS35 Homo sapiens

Full name:

VPS35, retromer complex component

Synonyms:

MEM3, PARK17, vacuolar protein sorting-associated protein 35, hVPS35, maternal-embryonic 3, vacuolar protein sorting 35 homolog

Genomic Location:

Chr 16: 45251090-45280645

Description:

This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex su...

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This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  TCANNTGAY_SREBP1_01 ,  CCTGTGA_MIR513 ,  GGGCGGR_SP1_Q6 ,  GTGCCTT_MIR506 ,  AP2_Q6 ,  CACBINDINGPROTEIN_Q6

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-124a

Cytogenetic Map:

16q11.2

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