Correlation Engine 2.0
Clear Search sequence regions
Bookmark Forward Export SNPs

QuickView for Vascular Endothelial Growth Factor A (gene)


Gene Symbol:
VEGFA Homo sapiens Homo sapiens
Full name:
vascular endothelial growth factor A
Synonyms:
MVCD1, VEGF, VPF, vascular endothelial growth factor A, vascular endothelial growth factor A121, vascular endothelial growth factor A165, vascular permeability factor
Genomic Location:
Chr 6: 43845931-43862202
Description:
This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abno...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Gallus gallus Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
TGGAAA_NFAT_Q4_01 SP1_01 CACTGCC_MIR34A_MIR34C_MIR449 FXR_Q3 TGANTCA_AP1_C DR3_Q4 CCCACAT_MIR2993P TTANTCA_UNKNOWN ZIC1_01 TGGNNNNNNKCCAR_UNKNOWN
miRNA binding sites
(Source: miRecords):
Cytogenetic Map:
chr 6
6p21.1





GO Molecular Function

platelet-derived growth factor receptor binding | vascular endothelial growth factor receptor 1 binding | signaling receptor binding | carbohydrate derivative binding | cytokine receptor binding | molecular function regulator | extracellular matrix binding | anion binding | vascular endothelial growth factor receptor 3 binding | identical protein binding | protein heterodimerization activity | vascular endothelial growth factor receptor binding | ion binding | heparin binding | vascular endothelial growth factor receptor 2 binding | protein binding | protein homodimerization activity | receptor regulator activity | protein dimerization activity | growth factor activity | receptor ligand activity | cytokine activity | chemoattractant activity | glycosaminoglycan binding | growth factor receptor binding | fibronectin binding

GO Biological Process

regulation of leukocyte chemotaxis | positive regulation of transcription from RNA polymerase II promoter in response to hypoxia | positive regulation of deacetylase activity | cell morphogenesis | cellular response to decreased oxygen levels | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | regulation of cysteine-type endopeptidase activity | exocytosis | response to cytokine | positive regulation of cellular component organization | cell motility | regulation of cell morphogenesis | regulation of neurogenesis | neuron projection morphogenesis | positive regulation of adherens junction organization | developmental process involved in reproduction | muscle tissue development | ovarian follicle development | regulation of cell development | regulation of localization | morphogenesis of an epithelium | induction of positive chemotaxis | positive regulation of DNA-binding transcription factor activity | regulation of axon extension involved in axon guidance | gonad development | regulation of programmed cell death | positive regulation of peptidyl-tyrosine phosphorylation | female gonad development | erythrocyte homeostasis | eye development | negative regulation of cysteine-type endopeptidase activity | smooth muscle cell differentiation | establishment of localization | blood vessel endothelial cell migration | regulation of immune system process | myeloid cell differentiation | platelet degranulation | regulation of cell shape | neuron migration | negative regulation of cellular process | positive regulation of histone deacetylase activity | positive regulation of developmental process | regulation of MAP kinase activity | negative regulation of RNA biosynthetic process | cell differentiation | positive regulation of epithelial cell proliferation | positive regulation of endothelial cell chemotaxis | respiratory tube development | striated muscle cell development | nervous system development | regulation of sprouting angiogenesis | epithelial cell migration | cell part morphogenesis | positive regulation of axonogenesis | neurogenesis | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | regulation of organelle organization | positive regulation of endothelial cell proliferation | positive regulation of cellular component movement | generation of neurons | cardiac cell development | tissue homeostasis | regulation of neuroblast proliferation | primitive erythrocyte differentiation | negative regulation of proteolysis | coronary artery morphogenesis | positive regulation of vascular endothelial growth factor receptor signaling pathway | blood vessel morphogenesis | positive regulation of cellular biosynthetic process | cellular process | secretion | regulation of cell motility | localization | cell projection morphogenesis | epithelial tube morphogenesis | cell maturation | commissural neuron axon guidance | heart morphogenesis | positive regulation of peptidyl-serine phosphorylation | neuron development | reproductive system development | regulation of vascular endothelial growth factor receptor signaling pathway | mesoderm development | epithelium migration | immune system development | negative regulation of nucleic acid-templated transcription | positive regulation of protein kinase activity | regulation of histone modification | regulation of chemotaxis | negative regulation of apoptotic process | response to hypoxia | axon guidance | regulation of proteolysis | response to growth factor | positive regulation of catalytic activity | regulation of tyrosine phosphorylation of STAT protein | positive regulation of nitrogen compound metabolic process | regulation of neuron projection development | positive regulation of cell division | negative regulation of cellular metabolic process | tissue development | regulation of cell differentiation | muscle structure development | anatomical structure homeostasis | muscle cell differentiation | regulation of angiogenesis | regulation of cellular process | positive regulation of cell growth | regulation of apoptotic process | regulation of metabolic process | positive regulation of stress-activated MAPK cascade | regulation of protein complex assembly | positive regulation of cellular protein metabolic process | epithelium development | regulation of axon guidance | coronary vasculature morphogenesis | cellular component organization | regulation of cell division | urogenital system development | positive regulation of epithelial cell migration | development of primary sexual characteristics | sprouting angiogenesis | lymph vessel morphogenesis | cardiac vascular smooth muscle cell development | positive regulation of stress-activated protein kinase signaling cascade | branching involved in blood vessel morphogenesis | regulation of vasculature development | response to stimulus | vasculature development | muscle cell development | cell morphogenesis involved in neuron differentiation | cellular response to vascular endothelial growth factor stimulus | positive regulation of cold-induced thermogenesis | respiratory system development | regulation of peptidyl-tyrosine phosphorylation | positive regulation of immune system process | positive regulation of protein metabolic process | positive regulation of protein kinase C signaling | cellular response to hypoxia | response to stress | neuron projection guidance | positive regulation of JAK-STAT cascade | endothelial cell migration | regulation of receptor internalization | post-embryonic camera-type eye development | regulation of cell proliferation | vascular smooth muscle cell differentiation | multicellular organismal homeostasis | positive regulation of neuroblast proliferation | tube morphogenesis | cardiac muscle tissue development | positive regulation of protein deacetylation | development of primary female sexual characteristics | reproduction | secretion by cell | regulation of histone deacetylase activity | cardiovascular system development | positive regulation of sprouting angiogenesis | macrophage differentiation | coronary vein morphogenesis | positive regulation of blood vessel endothelial cell migration | negative regulation of metabolic process | regulation of cellular component size | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | hemopoiesis | regulation of axon extension | regulation of mast cell chemotaxis | regulation of cell adhesion | kidney development | embryo development | regulation of morphogenesis of a branching structure | positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus | cell chemotaxis | muscle fiber development | activation of protein kinase activity | positive regulation of cell-matrix adhesion | molecular function regulator | eye photoreceptor cell differentiation | positive chemotaxis | blood vessel development | myeloid cell homeostasis | regulation of nucleic acid-templated transcription | leukocyte differentiation | regulation of cellular response to stress | locomotion | chemical homeostasis within a tissue | positive regulation of cell junction assembly | system development | response to oxygen levels | reproductive process | regulation of signal transduction | positive regulation of organelle organization | post-embryonic animal organ development | positive regulation of neuron projection development | regulation of adherens junction organization | multicellular organism development | negative regulation of catalytic activity | cell migration | regulation of peptidase activity | regulation of MAPK cascade | mammary gland development | regulation of axonogenesis | motor neuron migration | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | embryonic hemopoiesis | lymph vessel development | regulation of phosphorylation | negative regulation of peptidase activity | positive regulation of chromosome organization | monocyte differentiation | regulation of receptor-mediated endocytosis | artery development | positive regulation of receptor-mediated endocytosis | mammary gland lobule development | regulation of neuron differentiation | regulation of gene expression | positive regulation of chemotaxis | platelet-derived growth factor receptor signaling pathway | axon development | outflow tract morphogenesis | cellular response to stress | regulation of protein autophosphorylation | myeloid leukocyte differentiation | regulation of stem cell proliferation | positive regulation of protein kinase D signaling | coronary vasculature development | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | animal organ morphogenesis | positive regulation of axon extension involved in axon guidance | positive regulation of p38MAPK cascade | cellular response to oxygen levels | vascular endothelial growth factor signaling pathway | regulation of nitrogen compound metabolic process | regulation of cell migration | regulation of cell-substrate adhesion | enzyme linked receptor protein signaling pathway | regulation of cysteine-type endopeptidase activity involved in apoptotic process | positive regulation of cell projection organization | positive regulation of STAT cascade | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | cardiocyte differentiation | positive regulation of protein complex assembly | vesicle-mediated transport | positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway | regulation of cellular component movement | regulation of transcription by RNA polymerase II | primitive hemopoiesis | positive regulation of mast cell chemotaxis | regulation of cell migration involved in sprouting angiogenesis | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | axonogenesis | positive regulation of hydrolase activity | positive regulation of cell differentiation | regulation of endothelial cell migration | positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway | homeostasis of number of cells | positive regulation of cell migration | cellular response to cytokine stimulus | regulation of cellular protein metabolic process | positive regulation of transcription from RNA polymerase II promoter in response to stress | positive regulation of cell migration by vascular endothelial growth factor signaling pathway | cardiac muscle cell development | angiogenesis | surfactant homeostasis | regulated exocytosis | positive regulation of peptidyl-tyrosine autophosphorylation | cardiac muscle fiber development | cell morphogenesis involved in differentiation | post-embryonic development | regulation of leukocyte migration | sensory organ development | chordate embryonic development | positive regulation of histone deacetylation | striated muscle tissue development | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | eye morphogenesis | regulation of protein deacetylation | positive regulation of tyrosine phosphorylation of STAT protein | positive regulation of leukocyte chemotaxis | regulation of protein kinase C signaling | regulation of protein metabolic process | positive regulation of signal transduction | vasculogenesis | heart development | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of locomotion | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | renal system development | positive regulation of transport | eye photoreceptor cell development | striated muscle cell differentiation | regulation of cellular response to growth factor stimulus | venous blood vessel development | positive regulation of molecular function | positive regulation of axon extension | neuron differentiation | regulation of signaling receptor activity | receptor regulator activity | regulation of cell morphogenesis involved in differentiation | endothelial cell chemotaxis | positive regulation of focal adhesion assembly | positive regulation of protein modification process | regulation of growth | response to organic substance | gland development | tissue morphogenesis | cellular stress response to acid chemical | artery morphogenesis | branching morphogenesis of an epithelial tube | regulation of JAK-STAT cascade | lactation | regulation of kinase activity | regulation of animal organ morphogenesis | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | regulation of focal adhesion assembly | anatomical structure development | cell surface receptor signaling pathway | positive regulation of neurogenesis | growth factor activity | regulation of neural precursor cell proliferation | cell projection organization | positive regulation of cell development | regulation of DNA-templated transcription in response to stress | positive regulation of branching involved in ureteric bud morphogenesis | regulation of RNA biosynthetic process | developmental maturation | regulation of body fluid levels | negative regulation of transcription, DNA-templated | regulation of retinal ganglion cell axon guidance | negative regulation of programmed cell death | embryonic organ development | regulation of vesicle-mediated transport | chemical homeostasis | body fluid secretion | receptor ligand activity | neuron projection development | positive regulation of cellular component biogenesis | cytokine activity | positive regulation of axon guidance | negative regulation of biosynthetic process | chemoattractant activity | negative regulation of gene expression | animal organ development | positive regulation of histone modification | regulation of endothelial cell proliferation | positive regulation of cell-substrate adhesion | negative regulation of cellular protein metabolic process | positive regulation of leukocyte migration | positive regulation of kinase activity | regulation of phosphate metabolic process | regulation of chromosome organization | dopaminergic neuron differentiation | positive regulation of endothelial cell migration | positive regulation of MAPK cascade | lung development | morphogenesis of a branching epithelium | camera-type eye development | regulation of peptidyl-serine phosphorylation | mammary gland alveolus development | anatomical structure formation involved in morphogenesis | negative regulation of protein metabolic process | regulation of epithelial cell migration | positive regulation of CREB transcription factor activity | cardiac muscle cell differentiation | regulation of stress-activated MAPK cascade | regulation of cell communication | regulation of blood vessel endothelial cell migration | negative regulation of molecular function | positive regulation of developmental growth | signaling | positive regulation of growth | regulation of transcription, DNA-templated | cell development | positive regulation of cell migration involved in sprouting angiogenesis | regulation of endocytosis | regulation of developmental growth | regulation of epithelial cell proliferation | positive regulation of phosphorylation | regulation of cell size | regulation of transcription from RNA polymerase II promoter in response to stress | morphogenesis of a branching structure | anatomical structure morphogenesis | regulation of endopeptidase activity | positive regulation of stem cell proliferation | camera-type eye morphogenesis | positive regulation of MAP kinase activity | positive regulation of receptor internalization | reproductive structure development | regulation of nervous system development | regulation of developmental process | positive regulation of neural precursor cell proliferation | regulation of transcription from RNA polymerase II promoter in response to hypoxia | regulation of mesenchymal cell proliferation | developmental process | erythrocyte differentiation | vascular smooth muscle cell development | regulation of cell growth | positive regulation of protein autophosphorylation | vascular endothelial growth factor receptor signaling pathway | negative regulation of transcription by RNA polymerase II | tube development | regulation of cell junction assembly | regulation of transport | positive regulation of transcription, DNA-templated | positive regulation of retinal ganglion cell axon guidance | cell migration involved in sprouting angiogenesis | positive regulation of mesenchymal cell proliferation | positive regulation of kidney development | positive regulation of nucleic acid-templated transcription | photoreceptor cell development | epithelial cell differentiation | positive regulation of transcription by RNA polymerase II | venous blood vessel morphogenesis | negative regulation of hydrolase activity | regulation of histone deacetylation | tube formation | regulation of branching involved in ureteric bud morphogenesis | transmembrane receptor protein tyrosine kinase signaling pathway | cardiac vascular smooth muscle cell differentiation | in utero embryonic development | positive regulation of metabolic process | positive regulation of neuron differentiation | regulation of nitric oxide mediated signal transduction | regulation of cell projection organization | immune system process | hematopoietic or lymphoid organ development | female sex differentiation | ameboidal-type cell migration | photoreceptor cell differentiation | cellular response to organic substance | regulation of cell death | sex differentiation | positive regulation of cell motility | positive regulation of cell morphogenesis involved in differentiation | neuropilin signaling pathway | negative regulation of cell death | circulatory system development | positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis | chemotaxis | positive regulation of endocytosis | positive regulation of angiogenesis | regulation of cellular component organization | positive regulation of signaling | signal transduction | regulation of signaling | negative regulation of endopeptidase activity | regulation of p38MAPK cascade | positive regulation of gene expression | regulation of cell-matrix adhesion | VEGF-activated neuropilin signaling pathway | cellular response to growth factor stimulus | multicellular organismal process | regulation of chromatin organization | positive regulation of positive chemotaxis | regulation of phosphorus metabolic process

GO Cellular Component

secretory granule | extracellular matrix | cytoplasmic vesicle | cell | cytoplasmic vesicle lumen | cytoplasm | intracellular organelle | platelet alpha granule | secretory vesicle | endomembrane system | vesicle | extracellular region | membrane-bounded organelle | organelle | extracellular space | membrane-enclosed lumen | secretory granule lumen | intracellular vesicle | cell surface | intracellular | membrane | platelet alpha granule lumen | vesicle lumen