QuickView for Vav3 (gene)

Gene Symbol:

VAV3 Homo sapiens

Full name:

vav guanine nucleotide exchange factor 3

Synonyms:

guanine nucleotide exchange factor VAV3, VAV-3, vav 3 guanine nucleotide exchange factor, vav 3 oncogene

Genomic Location:

Chr 1: 107915305-108309068

Description:

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maxim...

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This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

STAT4_01 ,  ACACTCC_MIR122A ,  STAT6_02 ,  ACTGTGA_MIR27A_MIR27B ,  CTTTGTA_MIR524 ,  CATTTCA_MIR203 ,  P53_02 ,  ACCAAAG_MIR9 ,  AAAGACA_MIR511 ,  SOX5_01 ,  NRF1_Q6 ,  TGATTTRY_GFI1_01 ,  RCGCANGCGY_NRF1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-122a ,  Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-203 ,  Predicted Gene Targets for miR-31 ,  Predicted Gene Targets for miR-496

Cytogenetic Map:

1p13.3

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